Clinical Research Directory

Inclusion Criteria: Participant * Age 21 -75 years; * Non-progressive cervical SCI/spinal cord dysfunction (traumatic or non-traumatic); * Duration of SCI/spinal cord dysfunction more than or equal to 12 months; * ASIA Impairment scale (AIS B, C, or D) with impaired upper limb function; * At least one hand capable of grasp and pinch, with or without assistive modification; * International Standards for Neurological Classification of Spinal Cord Injury-Upper Extremity Measurement Scale (ISNCSCI-UEMS) more than or equal to 20; * Able to maintain an upright sitting position for at least 30 minutes; * No contraindication for tSCS (e.g., no pacemakers or other implantable stimulators); * Motivated and able to engage in a daily home-based rehabilitation program; * Availability of a dedicated care-giver to set up digital home-based therapy program Caregiver * Age 21 -75 years; * As identified by the patient as the caregiver; * Willing to participate in the study Exclusion Criteria: Participant * Significant or unstable medical co-morbidities including uncontrolled cardiopulmonary disease, severe cognitive impairment, severe dysautonomia, as determined by the investigator; * Pregnancy; * History of other neurologic conditions affecting upper limb function, such as stroke, multiple sclerosis, or traumatic brain injury; * Known history of peripheral neuropathy (diabetic polyneuropathy, entrapment neuropathy, etc); * Ongoing treatment for cancer; * Skin conditions or active cancerous lesion that limit the application of tSCS electrodes * Known contraindication for tSCS (pacemakers or other implantable stimulators); * Prior exposure to tSCS treatment; * Inability to provide informed consent. Caregiver: • Inability to provide informed consent.