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NUTRIMOOD-Inflammation and Depressive Comorbidity in Obesity: Modulation by Omega-3 Polyunsaturated Fatty Acids Status
Sponsor: National Science and Technology Council, Taiwan
Summary
A 12-week, randomized, placebo-controlled trial testing the efficacy of n-3 PUFA treatment (EPA, 2 g/day) in alleviating depressive symptoms in a subgroup of obese subjects with comorbid depression and low n-3 PUFA status (n-3 index \< 8%) (81), from the Taiwanese cohort. Associations with PLA2/COX2 genotypes, lifestyle, nutritional profiles and gut microbiota will also be determined.
Official title: Effects of 12-week n-3 PUFA Treatment (EPA) on Depressive Symptoms in Overweight/Obese Depressed Subjects With Low n-3 PUFA Status: Relationship With Systemic Inflammation
Key Details
Gender
All
Age Range
18 Years - 54 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2025-03-01
Completion Date
2027-12
Last Updated
2026-02-27
Healthy Volunteers
No
Conditions
Interventions
Eicosapentaenoic acid (omega-3 fatty acid)
25 participants are assigned
Placebo
25 participants are assigned
Locations (1)
Mind Body Interface Research Center (MBI Lab & Care)
Taichung, Taichung, Taiwan