Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)
Sponsor: EyeBiotech Ltd.
Summary
Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD). Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) can treat NVAMD. The goal of this trial is to learn if tiespectus works as well as aflibercept to treat NVAMD.
Official title: A Randomized Double-masked, Multicenter, 3-arm, Pivotal Phase 2/3 Study to Evaluate the Efficacy and Safety of Intravitreal (IVT) EYE201/MK-8748 Compared to Aflibercept (2 mg) in Participants With Neovascular Age-related Macular Degeneration (NVAMD)
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
INTERVENTIONAL
Enrollment
960
Start Date
2026-03-27
Completion Date
2028-06-30
Last Updated
2026-07-10
Healthy Volunteers
No
Conditions
Interventions
Tiespectus
Administered by intravitreal (IVT) injection
Aflibercept
Administered by intravitreal injection (IVT)
Locations (87)
Research Network Arizona / Retina Macula Institute of Arizona
Scottsdale, Arizona, United States
Retina Center of Arkansas
Fayetteville, Arkansas, United States
Retina Partners of Northwest Arkansas, PLLC
Springdale, Arkansas, United States
Global Research Management, Inc.
Glendale, California, United States
Retinal Consultants Medical Group (Site 024)
Modesto, California, United States
Retina Consultants of Southern California (Site 043)
Redlands, California, United States
Retinal Consultants Medical Group (Site 020)
Sacramento, California, United States
Retinal Consultants Medical Group (Site 022)
Sacramento, California, United States
Florida Eye Clinic (Site 130)
Altamonte Springs, Florida, United States
Retina Group of Florida (Site 070)
Fort Lauderdale, Florida, United States
Vitreo Retinal Associates
Gainesville, Florida, United States
Fort Lauderdale Eye Institute (Site 042)
Plantation, Florida, United States
Retina Vitreous Associates of Florida (Site 049)
St. Petersburg, Florida, United States
Southern Vitreoretinal Associates
Tallahassee, Florida, United States
Retina Associates of Florida, LLC
Tampa, Florida, United States
Retina Vitreous Associates of Florida
Tampa, Florida, United States
Wildwood Clinical Research / Florida Retina Institute
Wildwood, Florida, United States
Illinois Retina Associates
Oak Park, Illinois, United States
Associated Vitreoretinal and Uveitis Consultants
Carmel, Indiana, United States
Cumberland Valley Retina Consultants (Site 007)
Hagerstown, Maryland, United States
Foundation for Vision Research (Site 073)
Grand Rapids, Michigan, United States
Mississippi Retina Associates (Site 084)
Madison, Mississippi, United States
Mid Atlantic Retina
Cherry Hill, New Jersey, United States
ong Island Vitreoretinal Consultants / Vitreoretinal Consultants of NY (Site 105)
Hauppauge, New York, United States
Retina Vitreous Surgeons of CNY, PC (Site 033)
Liverpool, New York, United States
Piedmont Retina Specialists - Winston-Salem
Winston-Salem, North Carolina, United States
Cincinnati Eye Institute (Site 133)
Cincinnati, Ohio, United States
Tulsa Retina Consultants
Tulsa, Oklahoma, United States
Retina Northwest, PC
Portland, Oregon, United States
EyeHealth Northwest
Portland, Oregon, United States
Mid Atlantic Retina (Site 050)
Bethlehem, Pennsylvania, United States
Palmetto Retina Center
Aiken, South Carolina, United States
Charleston Neuroscience Institute - Bluffton (Site 124)
Bluffton, South Carolina, United States
Charleston Neuroscience Institute (Site 104)
Charleston, South Carolina, United States
Charleston Neuroscience Institute (CNI) d/b/a Retina Consultants of South Carolina
Mt. Pleasant, South Carolina, United States
Charles Retina Institute
Germantown, Tennessee, United States
Retina Research Institute of Texas (Site 010)
Abilene, Texas, United States
Southwest Retina Specialists
Amarillo, Texas, United States
Texas Retina Associates
Arlington, Texas, United States
Austin Research Center for Retina
Austin, Texas, United States
Austin Retina Associates (Site 012)
Austin, Texas, United States
Retina & Vitreous of Texas
Bellaire, Texas, United States
Texas Retina Associates
Dallas, Texas, United States
Texas Retina (Site 037)
Plano, Texas, United States
Retina Center of Texas
Southlake, Texas, United States
Retina Consultants of Texas (Site 014)
The Woodlands, Texas, United States
Strategic Clinical Research Group
Weatherford, Texas, United States
Retina Associates of Utah
Salt Lake City, Utah, United States
Piedmont Eye Center (Site 054)
Lynchburg, Virginia, United States
Pacific Northwest Retina (Site 112)
Burlington, Washington, United States
Spokane Eye Clinical Research (Site 075)
Spokane, Washington, United States
Grupo Laser Vision (Rosario Eximer Laser Vision SA)
Rosario, Santa Fe Province, Argentina
Oftalmología Global (Centro Médico Oftalmología Global) (Site 304)
Rosario, Santa Fe Province, Argentina
Microcirugia Ocular Rosario (Site 310)
Rosario, Santa Fe Province, Argentina
Centro de Ojos Quilmes
Buenos Aires, Argentina
Fundacion Jorge Zambrano para la investigación, diagnostivo y tratamiento de enfermedades oculares (Site 302)
Buenos Aires, Argentina
RSresearch (Site 308)
Buenos Aires, Argentina
Instituto Oftalmologico de Buenos Aires SA (Site 306)
Buenos Aires, Argentina
Centro Oftalmologico Dr Charles y Asociados (Site 300)
Buenos Aires, Argentina
Centro de Ojos Loria SRL (Site 312)
Buenos Aires, Argentina
Centro Oftalmológico Dr. Zas
Buenos Aires, Argentina
Instituto Donato
Cdad. Autónoma de Buenos Aires, Argentina
Instituto de Microcirugía Ocular Córdoba (IMOC S.R.L) (Site 305)
Córdoba, Argentina
Centro Privado de Ojos Romagosa SA (Site 307)
Córdoba, Argentina
Centrovision Clinica Oftalmologica
Mendoza, Argentina
Oftar Centro De Oftalmología en Mendoza
Mendoza, Argentina
Centro de la Visión (Site 309)
Salta, Argentina
Instituto Zeman Bardeci (Site 311)
Salta, Argentina
Eye Clinic Albury Wodonga (Site 425)
Albury, Australia
Marsden Eye Specialists (Site 420)
Parramatta, Australia
Marsden Eye Specialists (Site 423)
Strathfield, Australia
Sydney Eye Hospital (Site 426)
Sydney, Australia
Sydney Retina Clinic and Day Surgery (Site 424)
Sydney, Australia
Barzilai Medical Center
Ashkelon, Israel
Rambam Health Corporation (Site 706)
Haifa, Israel
Carmel Medical Center (Site 704)
Haifa, Israel
Hadassah Medical Center Opthalmology Department (Site 701)
Jerusalem, Israel
Rabin Medical Center (Site 700)
Petah Tikva, Israel
Sheba Medical Center (Site 707)
Ramat Gan, Israel
Kaplan Medical Center Ophthalmology Department (Site 705)
Rehovot, Israel
Shamir Medical Center (Site 703)
Ẕerifin, Israel
P.Stradins clinical university hospital
Riga, Latvia
University Hospital Basel, Eye Clinic
Basel, Switzerland
Swiss Eye Institute and Berner Augenklinik
Bern, Switzerland
Vista Augenklinik Binningen
Binnigen, Switzerland
University Hospitals of Leicester NHS Trust (Site 209)
Leicester, United Kingdom
London North West University Healthcare NHS Trust (LNWH) (Site 201)
London, United Kingdom