Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)
Sponsor: EyeBiotech Ltd.
Summary
Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD). Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) can treat NVAMD. The goal of this trial is to learn if tiespectus works as well as aflibercept to treat NVAMD.
Official title: A Randomized Double-masked, Multicenter, 3-arm, Pivotal Phase 2/3 Study to Evaluate the Efficacy and Safety of Intravitreal (IVT) EYE201/MK-8748 Compared to Aflibercept (2 mg) in Participants With Neovascular Age-related Macular Degeneration (NVAMD)
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
INTERVENTIONAL
Enrollment
960
Start Date
2026-03-27
Completion Date
2028-06-30
Last Updated
2026-05-04
Healthy Volunteers
No
Conditions
Interventions
Tiespectus
Administered by intravitreal (IVT) injection
Aflibercept
Administered by intravitreal injection (IVT)
Locations (30)
Retina Partners of Northwest Arkansas, PLLC
Springdale, Arkansas, United States
Global Research Management, Inc.
Glendale, California, United States
Retinal Consultants Medical Group (Site 024)
Modesto, California, United States
Retina Consultants of Southern California (Site 043)
Redlands, California, United States
Retinal Consultants Medical Group (Site 020)
Sacramento, California, United States
Retinal Consultants Medical Group (Site 022)
Sacramento, California, United States
Retina Group of Florida (Site 070)
Fort Lauderdale, Florida, United States
Fort Lauderdale Eye Institute (Site 042)
Plantation, Florida, United States
Retina Vitreous Associates of Florida (Site 049)
St. Petersburg, Florida, United States
Retina Associates of Florida, LLC
Tampa, Florida, United States
Retina Vitreous Associates of Florida
Tampa, Florida, United States
Illinois Retina Associates
Oak Park, Illinois, United States
Cumberland Valley Retina Consultants (Site 007)
Hagerstown, Maryland, United States
Foundation for Vision Research (Site 073)
Grand Rapids, Michigan, United States
Mississippi Retina Associates (Site 084)
Madison, Mississippi, United States
ong Island Vitreoretinal Consultants / Vitreoretinal Consultants of NY (Site 105)
Hauppauge, New York, United States
Retina Vitreous Surgeons of CNY, PC (Site 033)
Liverpool, New York, United States
Tulsa Retina Consultants
Tulsa, Oklahoma, United States
EyeHealth Northwest
Portland, Oregon, United States
Palmetto Retina Center
Aiken, South Carolina, United States
Charleston Neuroscience Institute - Bluffton (Site 124)
Bluffton, South Carolina, United States
Charleston Neuroscience Institute (Site 104)
Charleston, South Carolina, United States
Retina Research Institute of Texas (Site 010)
Abilene, Texas, United States
Austin Research Center for Retina
Austin, Texas, United States
Austin Retina Associates (Site 012)
Austin, Texas, United States
Texas Retina (Site 037)
Plano, Texas, United States
Retina Consultants of Texas (Site 014)
The Woodlands, Texas, United States
Retina Associates of Utah
Salt Lake City, Utah, United States
Piedmont Eye Center (Site 054)
Lynchburg, Virginia, United States
Pacific Northwest Retina (Site 112)
Burlington, Washington, United States