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triPle Oral thERapy With Bempedoic Acid vs uSual Care in Early Lipid Management of Patients With acUte coronAry synDromE
Sponsor: Heart Care Foundation
Summary
Early and intensive LDL-cholesterol (LDL-c) reduction is associated with improved short-term and long-term outcomes. Bempedoic acid is an oral ATP citrate lyase inhibitor that lowers LDL-c upstream of HMG-CoA reductase. When added to maximally tolerated statins, it has demonstrated significant LDL-c reduction and cardiovascular benefit, particularly in statin-intolerant or high-risk patients. However, evidence on early initiation of bempedoic acid during the index ACS hospitalization is currently lacking. The investigators therefore would like to see whether early (pre-discharge) initiation of an oral triple lipid-lowering therapy including bempedoic acid, high-intensity statin (HIS), and ezetimibe is superior to usual care in reducing LDL-c levels at 8 weeks after randomization in patients hospitalized for ACS.
Official title: triPle Oral thERapy With Bempedoic Acid vs uSual Care in Early Lipid Management of Patients With acUte coronAry synDromE (PERSUADE) Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
600
Start Date
2026-09
Completion Date
2027-08
Last Updated
2026-02-27
Healthy Volunteers
No
Interventions
Triple oral lipid lowering treatment
Triple oral lipid lowering treatment including high intensity statin, ezetimibe and bembedoic acid
Locations (35)
Ospedale Miulli - U.O.C. CARDIOLOGIA - UTIC
Acquaviva delle Fonti, Italy
Ospedale Della Murgia - Fabio Perinei - S.C. Cardiologia-Utic
Altamura, Italy
Ospedale San Donato - U.O.C Cardiologia
Arezzo, Italy
Aorn San Giuseppe Moscati - U.O. Cardiologia/Utic 'D. Rotiroti'
Avellino, Italy
Ospedale San Paolo - Cardiologia-Utic
Bari, Italy
Ospedale Santo Spirito - SC Cardiologia
Casale Monferrato, Italy
Azienda Ospedaliera S. Anna E S. Sebastiano - U.O. Cardiologia D'Emergenza Con Utic
Caserta, Italy
Azienda Ospedaliera Cannizzaro - Uoc Cardiologia
Catania, Italy
OSPEDALE PIO XI - UOC di Cardiologia
Desio, Italy
Presidio Ospedaliero "Santa Maria Del Prato" - U.O.C. Di Cardiologia-Utic
Feltre, Italy
Arcispedale Sant'Anna - U.O. Cardiologia
Ferrara, Italy
Aou Careggi - Interventistica Cardiologica Strutturale
Florence, Italy
Policlinico Riuniti - S.C. Di Cardiologia Universitaria-Utic
Foggia, Italy
Ospedale Del Tigullio Polo Lavagna - Sc Cardiologia E Utic
Lavagna, Italy
OSPEDALE CIVILE FORNAROLI - UO Cardiologia
Magenta, Italy
Asst Ospedale Metropolitano Niguarda - Cardiologia 1 - Emodinamica
Milan, Italy
Fondazione Irccs Ca' Granda Ospedale Maggiore Policlinico - Uoc Malattie Cardiovascolari
Milan, Italy
Irccs Ospedale Galeazzi - Sant'Ambrogio - Cardiologia Universitaria Ed Imaging Cardiaco
Milan, Italy
Ospedale Policlinico - Uoc Di Cardiologia
Modena, Italy
Aou Policlinico P. Giaccone - U.O.C. Cardiologia
Palermo, Italy
Arnas P.O. Civico E Benfratelli - Uoc Utic
Palermo, Italy
FONDAZIONE IRCCS POLICLINICO SAN MATTEO - UOC Cardiologia
Pavia, Italy
Ospedale Santo Spirito - Cardiologia Con Utic
Pescara, Italy
Ospedale San Jacopo - Soc Cardiologia
Pistoia, Italy
Aor San Carlo - Ospedale San Carlo - Ssd Terapia Intensiva Cardiologica
Potenza, Italy
Ospedale Giovanni Paolo Ii - U.O.C. Cardiologia-Utic
Ragusa, Italy
Po Santa Maria Nuova - Ausl Re Irccs - Soc Cardiologia Ospedaliera
Reggio Emilia, Italy
OSPEDALE DEGLI INFERMI - SC Cardiologia
Rivoli, Italy
Ospedale San Camillo - Uoc Cardiologia
Roma, Italy
P.O. San Filippo Neri - Asl Roma 1 - Cardiologia Clinica E Riabilitativa
Roma, Italy
PRESIDIO OSPEDALIERO - UO Cardiologia
Sanremo, Italy
P.O. Levante - Ospedale San Paolo - S.C. Cardiologia Levante
Savona, Italy
OSPEDALE SANTA CHIARA - Divisione di Cardiologia
Trento, Italy
OSPEDALE CA' FONCELLO - UOC Cardiologia
Treviso, Italy
Nuovo Ospedale Di Vimercate - S.C. Cardiologia E Utic
Vimercate, Italy