Clinical Research Directory

Inclusion Criteria: 1. Menopausal women aged \>40 to 45 years with intact uterus and ovaries. 2. Participants who complained of irregular menstrual cycle in the past 12 months, with a forward or postpone of a cycle more 7 days. At least 2 cycles were missing during the past 12 months or reported menopause for at least 60 days. 3. Females with complaints of at least two of the menopausal symptoms, e.g., hot flashes, night sweats, mood swings, sleep disturbance, breast tenderness 4. Body mass index 18-35 kg/m2 5. Subject who has given written informed consent to participate in the study and understand the nature of the study. 6. Able to read and write in English or any other vernacular language. 7. No plan to commence new treatments over the study period. 8. Must have the ability and willingness to si Exclusion Criteria: 1. Participants taking any form of herbal extract in the last 3 months before study entry. 2. Participants who are on hormone replacement therapy (HRT) for more than 3 months. 3. Participants who are pregnant. 4. Participants with present active medical, surgical, and gynaecological problems. 5. Participants with a history of alcohol, tobacco dependence, or any substance abuse. 6. Participants who had undergone bilateral ovariectomy 7. Participants with history of breast or cervical carcinoma 8. Participants who taking medication that affect bone metabolism, including glucocorticoid, anticonvulsant, and methotrexate. 9. Participants with clinically relevant cardiovascular, gastrointestinal, hepatic, neurologic, endocrine, haematologic or other major systemic diseases making implementation of the protocol or other interpretation of the study result difficult. 10. Participants with mental condition rendering the subject unable to understand the nature, scope, and possible consequences of the study. 11. Participants with evidence of demonstrated inability to follow study protocols or attend follow-up visits, including poor compliance. 12. Participants with demonstrated inability to follow study protocols or attend follow-up visit 13. Participants with inability to attend follow-up visit 14. Participants with any other medical condition (for example uncontrolled infection) that may, in the opinion of the Investigator, interfere with the study objective. 15. Patients who had participated in other clinical trials during the previous 3 months. 16. Patients who have any clinical condition, according to the investigator, who does not allow safe fulfilment of clinical trial protocol.