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Does Circadian Misalignment Have Sex-Specific Effects on Metabolism?
Sponsor: Brigham and Women's Hospital
Summary
This study will test whether biological sex influences how the body responds to circadian misalignment-a mismatch between the internal body clock and the timing of sleep and eating (as can occur with shift work or jet lag). Researchers will examine how circadian misalignment affects appetite regulation (hunger/fullness) and glucose metabolism (blood sugar control), and whether these effects differ between females and males. Findings may help inform more personalized shift work schedules and targeted strategies to reduce metabolic health risks and sex-related differences in clinical care.
Official title: Role of Biological Sex in Metabolic Responses to Night Work
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
36
Start Date
2026-10-01
Completion Date
2030-09-30
Last Updated
2026-02-27
Healthy Volunteers
Yes
Conditions
Interventions
Day shift
Research participants will be assigned to day shift condition in which sleep-wake and meal schedules are aligned with the internal circadian system
Night shift
Research participants will be assigned to simulated night shift condition in which sleep-wake and meal schedules are misaligned with the internal circadian system
Locations (1)
Brigham and Women's Hospital
Boston, Massachusetts, United States