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NOT YET RECRUITING
NCT07442058
NA

Accelerated and Extended-iTBS Targeting Inhibitory Control in Veterans With ADHD

Sponsor: VA Office of Research and Development

View on ClinicalTrials.gov

Summary

Impaired inhibitory response manifests clinically as increased impulsivity, which leads to poorer affective, cognitive, social, and occupational functioning. Neuropsychiatric disorders prevalent among Veterans, such as Attention Deficit/Hyperactivity Disorder (ADHD), are associated with poor inhibitory control. The mainstay of clinical treatment for ADHD is psychostimulants, yet these medications have significant risks, including dependence and numerous side effects. Thus, novel and non-pharmacological therapeutic strategies are needed. Intermittent Theta Burst Stimulation, a newer form of transcranial magnetic stimulation, has emerged as a promising tool for modulating inhibitory neuronal circuits. This research proposal will investigate the feasibility and acceptability of iTBS on inhibitory control and impulsivity through a randomized controlled trial to inform clinical observations. The long-term goal is to improve impulsivity, social and occupational functioning, and enhance the quality of life for Veterans.

Official title: ACHIEVE: Accelerated and Extended-rTMS to Heighten Inhibitory Control Engagement in Veterans

Key Details

Gender

All

Age Range

18 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

35

Start Date

2026-07-01

Completion Date

2028-07-01

Last Updated

2026-03-02

Healthy Volunteers

No

Interventions

DEVICE

Intermittent Theta-Burst Stimulation

Theta Burst Stimulation is a second-generation TMS modality. iTBS enhances cortical excitability, facilitating synaptic connections through putative long-term potentiation-like effects. In addition, iTBS also stands out given its favorable safety profile and its brief administration time.

DEVICE

Sham Stimulation

Sham will be administered using equivalent procedures but with a sham coil.

Locations (1)

Providence VA Medical Center, Providence, RI

Providence, Rhode Island, United States