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Accelerated and Extended-iTBS Targeting Inhibitory Control in Veterans With ADHD
Sponsor: VA Office of Research and Development
Summary
Impaired inhibitory response manifests clinically as increased impulsivity, which leads to poorer affective, cognitive, social, and occupational functioning. Neuropsychiatric disorders prevalent among Veterans, such as Attention Deficit/Hyperactivity Disorder (ADHD), are associated with poor inhibitory control. The mainstay of clinical treatment for ADHD is psychostimulants, yet these medications have significant risks, including dependence and numerous side effects. Thus, novel and non-pharmacological therapeutic strategies are needed. Intermittent Theta Burst Stimulation, a newer form of transcranial magnetic stimulation, has emerged as a promising tool for modulating inhibitory neuronal circuits. This research proposal will investigate the feasibility and acceptability of iTBS on inhibitory control and impulsivity through a randomized controlled trial to inform clinical observations. The long-term goal is to improve impulsivity, social and occupational functioning, and enhance the quality of life for Veterans.
Official title: ACHIEVE: Accelerated and Extended-rTMS to Heighten Inhibitory Control Engagement in Veterans
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
35
Start Date
2026-07-01
Completion Date
2028-07-01
Last Updated
2026-03-02
Healthy Volunteers
No
Interventions
Intermittent Theta-Burst Stimulation
Theta Burst Stimulation is a second-generation TMS modality. iTBS enhances cortical excitability, facilitating synaptic connections through putative long-term potentiation-like effects. In addition, iTBS also stands out given its favorable safety profile and its brief administration time.
Sham Stimulation
Sham will be administered using equivalent procedures but with a sham coil.
Locations (1)
Providence VA Medical Center, Providence, RI
Providence, Rhode Island, United States