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Impact of Low Dose Epinephrine in the Management of Out-of-hospital Cardiac Arrest on Neurological Outcome
Sponsor: Central Hospital, Nancy, France
Summary
This study will test whether a lower dose of epinephrine (0.5 mg) given during emergency treatment for out-of-hospital cardiac arrest helps more patients survive with good brain function, compared to the standard dose (1 mg). Adults who experience cardiac arrest outside the hospital and are treated by emergency medical teams will be randomly assigned to receive either the low dose or the standard dose of epinephrine. The study will compare survival and neurological outcomes between the two groups over 28 days.
Official title: Impact of Low Dose Epinephrine in the Management of Out-of-hospital Cardiac Arrest on Neurological Outcome: A Multicenter Randomized and Double-blind Trial.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
4336
Start Date
2026-06
Completion Date
2030-07
Last Updated
2026-03-02
Healthy Volunteers
No
Conditions
Interventions
Epinephrine 0.5 mg intravenous bolus
Epinephrine 0.5 mg/mL solution for injection, administered as a 0.5 mg intravenous bolus every 3 to 5 minutes during cardiopulmonary resuscitation (CPR) for out-of-hospital cardiac arrest. T
Epinephrine 1 mg intravenous bolus
Epinephrine 1 mg/mL solution for injection, administered as a 1 mg intravenous bolus every 3 to 5 minutes during cardiopulmonary resuscitation (CPR) for out-of-hospital cardiac arrest.
Locations (26)
CH Annecy
Annecy, France
Centre hospitalier de la Côte Basque
Bayonne, France
CHU Besancon
Besançon, France
CHU Brest
Brest, France
CHU Colmar
Colmar, France
CH SUD Francilien
Corbeil-Essonnes, France
Brigade de Sapeurs-Pompiers de Paris
Courbevoie, France
Centre Hospitalier Universitaire Grenoble Alpes
La Tronche, France
Hospices Civils De Lyon
Lyon, France
CHU Montpellier
Montpellier, France
CHRU Nancy
Nancy, France
Centre Hospitalier Universitaire De Nantes
Nantes, France
CHU Nice
Nice, France
CHU Nimes
Nîmes, France
AP-HP Hôpital Necker
Paris, France
Hopital Beaujon
Paris, France
hôpital Lariboisière
Paris, France
La Pitié Salpêtrière
Paris, France
Raymond Poincaré Hospital
Paris, France
CHU Poitiers
Poitiers, France
Centre Hospitalier Universitaire Reims
Reims, France
CHU Rennes
Rennes, France
CHU Rouen
Rouen, France
Centre hospitalier Annecy Genevois Site Julien en GENEVOIS
Saint-Julien-en-Genevois, France
Centre Hospitalier Universitaire De Toulouse
Toulouse, France
CHU Tours
Tours, France