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Neural Mechanisms of Aerobic Exercise Benefits in PD With DBS
Sponsor: The Cleveland Clinic
Summary
This study is focused on people with Parkinson's disease who already have deep brain stimulation devices. The goal is to understand how aerobic exercise, specifically forced vs voluntary cycling, affects movement, thinking, and brain activity in these individuals. Parkinson's disease is a progressive condition that impacts both movement and cognitive function. Previous research suggests aerobic exercise can improve PD symptoms, but the mechanisms underlying the improvement are not fully understood. This study aims to evaluate the neural (brain) mechanisms underlying exercise.
Official title: Neural Mechanisms Underlying the Benefits of Aerobic Exercise in Advanced Parkinson's Disease
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
36
Start Date
2026-05-01
Completion Date
2029-12-31
Last Updated
2026-03-02
Healthy Volunteers
No
Interventions
Exercise
Participants will complete an eight-week control period followed by an eight-week cycling program. They will complete 3 sessions per week in-person with a member of the study team, for a total of 24 exercise sessions.