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Treatment for Ph-negative ALL for Adults up to 65 Years
Sponsor: PETHEMA Foundation
Summary
The goal of this trial is to provide a protocol for treatment for adults with Ph-negative acute lymphoblastic leukemia (ALL) and to learn if this provides higher probability of survival than the previous one. The main question is to know if the incorporation of blinatumomab for B-cell precursor ALL, substituting some chemotherapy blocks, offers better probability of survival than the previous trial, which did not use immunotherapy. In addition, T-cell precursor ALL participants will receive different treatment approaches depending on the stage of maturation of the tumor.
Official title: Protocol for the Treatment of BCR::ABL1-negative Acute Lymphoblastic Leukemia in Adults up to 65 Years
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
330
Start Date
2026-03-06
Completion Date
2033-06-01
Last Updated
2026-03-02
Healthy Volunteers
No
Conditions
Interventions
Pediatric-type of chemotherapy (+blinatumomab for B-cell precursor ALL)
Pediatric type chemotherapy (induction, early and delayed consolidation, reinduction, maintenance). Induction (VCR,PDN,PegASP,DNR). Early and delayed consolidation (high-dose Methotrexate, high-dose Cytarabine, PegASP). Reinduction (VCR, PDN, PegASP, DNR). Maintenance (Methotrexate, Mercaptopurine). Blinatumomab cycles in consolidation therapy for participants with B-cell precursor ALL.
Transplantation
allogeneic stem cell transplantation
Locations (95)
Hospital de A Coruña
A Coruña, Spain
Hospital Universitario de Araba
Alava, Spain
Hospital General Universitario de Albacete
Albacete, Spain
Hospital General Universitario Dr. Balmis
Alicante, Spain
Hospital Universitario Torrecárdenas
Almería, Spain
Hospital General de Lanzarote
Arrecife, Spain
Hospital Nuestra Señora de Sonsoles / Complejo Asistencial de Ávila
Ávila, Spain
Hospital Universitario de Badajoz
Badajoz, Spain
ICO-Hospital Germans Trias i Pujol
Badalona, Spain
Hospital Clínic de Barcelona
Barcelona, Spain
Hospital de Sant Pau
Barcelona, Spain
Hospital del Mar
Barcelona, Spain
Hospital QuirónSalud
Barcelona, Spain
Hospital Vall d'Hebrón
Barcelona, Spain
Basurtuko Ospitalea
Bilbao, Spain
Hospital Universitario de Burgos
Burgos, Spain
Hospital Puerta del Mar
Cadiz, Spain
Hospital Universitario Santa Lucía
Cartagena, Spain
Hospital General de Castellón
Castelló, Spain
Hospital San Pedro Alcántara
Cáceres, Spain
Hospital General de Ciudad Real
Ciudad Real, Spain
Hospital Universitario Reina Sofía
Córdoba, Spain
Hospital Universitario de Cruces
Cruces, Spain
Hospital Virgen de la Luz
Cuenca, Spain
Hospital Universitario de Donostia
Donostia / San Sebastian, Spain
Hospital de Fuenlabrada
Fuenlabrada, Spain
Hospital Universitario de Galdakao
Galdakao, Spain
Hospital de Getafe
Getafe, Spain
ICO-Hospital Josep Trueta
Girona, Spain
Area Hospitalaria Juan Ramón Jimenez
Huelva, Spain
Consorcio Hospitalario de Jaén
Jaén, Spain
Hospital Jerez de la Frontera
Jerez de la Frontera, Spain
ICO-Hospital Duran i Reynals
L'Hospitalet de Llobregat, Spain
C. H. U. de Gran Canaria Dr. Negrín
Las Palmas de Gran Canaria, Spain
Complejo Hospitalario Universitario Insular Materno Infantil de Canarias
Las Palmas de Gran Canaria, Spain
Hospital Severo Ochoa
Leganés, Spain
Hospital Universitario de León
León, Spain
Hospital Arnau de Vilanova
Lleida, Spain
Hospital San Pedro
Logroño, Spain
Hospital Universitario Lucus Augusti
Lugo, Spain
C. H. Gregorio Marañón
Madrid, Spain
Clínica Universidad Navarra
Madrid, Spain
Hospital Clínico San Carlos
Madrid, Spain
Hospital Doce de Octubre
Madrid, Spain
Hospital Infanta Leonor
Madrid, Spain
Hospital La Princesa
Madrid, Spain
Hospital La Zarzuela
Madrid, Spain
Hospital Príncipe de Asturias
Madrid, Spain
Hospital Ramón y Cajal
Madrid, Spain
Hospital Ruber Juan Bravo
Madrid, Spain
Hospital Sanchinarro
Madrid, Spain
Hospital Universitario Fundación Jiménez Díaz
Madrid, Spain
Hospital Universitario HLA Moncloa
Madrid, Spain
Hospital Universitario Infanta Sofía
Madrid, Spain
Hospital Universitario La Paz
Madrid, Spain
Hospital Universitario Quirónsalud
Madrid, Spain
MD Anderson Cancer Center
Madrid, Spain
Hospital Puerta de Hierro
Majadahonda, Spain
. Hospital Clínico Universitario Virgen de la Victoria
Málaga, Spain
Hospital QuirónSalud
Málaga, Spain
Hospital Regional Universitario de Málaga (Carlos Haya)
Málaga, Spain
Hospital Morales Meseguer
Murcia, Spain
Hospital Virgen de la Arrixaca
Murcia, Spain
Complejo Hospitalario Universitario de Ourense
Ourense, Spain
Hospital Central de Asturias
Oviedo, Spain
Complejo Asistencial de Palencia
Palencia, Spain
Hospital Son Espases
Palma de Mallorca, Spain
Hospital Universitari Son Llàtzer
Palma de Mallorca, Spain
Clínica Universidad Navarra
Pamplona, Spain
Hospital Universitario de Navarra
Pamplona, Spain
Complejo Hospitalario Pontevedra (CHUP)-Montecelo
Pontevedra, Spain
C. Asistencial U. de Salamanca
Salamanca, Spain
Hospital Nuestra Señora Candelaria
Santa Cruz de Tenerife, Spain
Hospital Universitario de Canarias
Santa Cruz de Tenerife, Spain
Hospital Universitario Marqués de Valdecilla
Santander, Spain
C H Santiago de Compostela
Santiago de Compostela, Spain
Hospital General de Segovia
Segovia, Spain
Consoorcio Hospitalario Virgen de Valme
Seville, Spain
Hospital Virgen de la Macarena
Seville, Spain
Hospital Virgen del Rocío
Seville, Spain
ICO-Hospital Joan XXIII
Tarragona, Spain
Hospital Universitari Mútua Terrassa
Terrassa, Spain
Hospital Universitario de Toledo
Toledo, Spain
Hospital Universitario de Torrejón
Torrejón de Ardoz, Spain
Hospital Arnau de Vilanova
Valencia, Spain
Hospital Clínico de Valencia
Valencia, Spain
Hospital Doctor Peset
Valencia, Spain
Hospital General de Valencia
Valencia, Spain
Hospital Universitari i Politècnic La Fe
Valencia, Spain
Hospital Clínico Universitario de Valladolid
Valladolid, Spain
Hospital Río Hortega
Valladolid, Spain
Hospital Álvaro Cunqueiro
Vigo, Spain
Complejo Asistencial de Zamora
Zamora, Spain
Hospital Lozano Blesa
Zaragoza, Spain
Hospital Miguel Servet
Zaragoza, Spain