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Cardiac Output and Fatigue in Friedreich's Ataxia
Sponsor: Scott Barbuto
Summary
This is a clinical trial examining to impact of aerobic training plus omaveloxolone in FRDA. Thirty individuals with FRDA will be recruited; 20 individuals will be on omaveloxolone treatment whereas the other ten individuals will not. Individuals will undergo baseline assessment including cardiopulmonary exercise testing (CPET), mFARS, gait speed, Timed Up and Go (TUG), Fatigue Severity Scale (FSS), Fatigue Impact Scale (FIS), and 6-minute Walk Test (6MWT). Individuals will then perform 3-months of home aerobic training. Repeat assessments will be conducted at 3- and 6-months.
Key Details
Gender
All
Age Range
Any - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2026-07-15
Completion Date
2028-04-01
Last Updated
2026-09-22
Healthy Volunteers
No
Conditions
Interventions
Aerobic Exercise
Both groups will receive aerobic training. The difference will be whether individuals are on or off omaveloxolone.
Locations (1)
Columbia University Irving Medical Center
New York, New York, United States