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Feasibility of a Multi-omics Platform for Hematological Malignancies
Sponsor: Azienda Ospedaliero-Universitaria di Parma
Summary
This is a biological study based on a collaborative effort involving several Italian haematology centres (including the coordinating centre). The study will be conducted retrospectively and prospectively using bone marrow (BM) or peripheral blood (PB) samples, lymph node or tissue biopsies with metastatic involvement, and other biological fluids, such as cerebrospinal fluid and pathological pleural effusion.
Key Details
Gender
All
Age Range
2 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1040
Start Date
2025-03-31
Completion Date
2030-03
Last Updated
2026-03-03
Healthy Volunteers
No
Conditions
Interventions
Multi-omics analyses
The focus of our scientific approach is based on multi-omics analyses: NGS (Next Generation Sequencing analysis), Bulk Transcriptomics, Single-cell resolution, Single-cell transcriptomics and phosphoproteomics.
Functional tests
Functional analyses will be performed on primary sample from each enrolled patient. Malignant cells are cultered and incubated with a specific library of drugs (300 drugs) at four different concentrations for 72 hours.
Locations (1)
University of Parma
Parma, PR, Italy