Clinical Research Directory

Inclusion Criteria: 1. Hemodynamic stability within 24 hours following treatment for acute coronary syndrome 2. A confirmed prior diagnosis of ischemic cerebrovascular disease, or the presence of intracranial or extracranial arterial stenosis ≥50%, as verified by carotid and cerebrovascular ultrasound after admission 3. Manifestations consistent with fire-heat syndrome, including tongue body appearance, tongue coating, stool characteristics, mental state, facial complexion, breathing pattern, presence of fever, pulse features, oral sensation, and urine properties. A total score of ≥7 points based on the weighted scoring system for each item indicates the presence of fire-heat syndrome. 4. Age ≥ 60 years old Exclusion Criteria: 1. Patients with persistent hemodynamic instability beyond 24 hours, or those with ACS-related hypotension (SBP \< 90 mmHg or DBP \< 60 mmHg), or requiring coronary artery bypass grafting based on coronary artery lesions 2. History of chronic heart failure due to any cause 3. History of ischemic stroke, peptic ulcer, active bleeding, or major surgery within the past 3 months 4. Hepatic or renal dysfunction, defined as ALT or AST levels \>5 times the upper limit of normal, or estimated glomerular filtration rate (eGFR) \<30 mL/min/1.73m² 5. Previous history of bronchial asthma 6. Platelet count \<80×10⁹/L or anemia (hemoglobin ≤100 g/L) 7. Contraindication or allergy to aspirin, clopidogrel, ticagrelor, or statins 8. History of malignant tumor 9. Known allergy to components of traditional Chinese medicine