Clinical Research Directory

Inclusion Criteria: * Patient aged \>1 year old, referred for evaluation to the University Hospital of Parma; * Retrospective study: previously patients with hematological malignancies; * Prospective study: 1) patients with clinical suspect of hematological malignancies which requires a diagnostic assessment using peripheral blood drawn, bone marrow aspirate/biopsy, lymph nodes biopsies or biopsies of tissues with metastatic involvement including liquor from rachicentesis, tissue aspirate etc. 2) patients with clinical suspect of relapsed/refractory onco-hematological disorder, which requires a diagnostic assessment using bone marrow aspirate/biopsy or biopsies of tissues with metastatic involvement including lymph nodes, liquor from rachicentesis, tissue aspirate etc. 3) patients that progress in blastic transformation from a chronic condition or suspect of relapsed/refractory hematological disease, which requires a diagnostic assessment using peripheral blood drawn, bone marrow aspirate/biopsy, lymph nodes biopsies or biopsies of tissues with metastatic involvement including liquor from rachicentesis, tissue aspirate etc; * Written informed consent. Retrospective study: informed consent will be signed during the first follow-up visit. Exclusion Criteria: * Age \<1 year old * Patients who are unable to provide informed consent prior to any procedure for any reason.