Clinical Research Directory

Inclusion Criteria: * Able and willing to provide informed consent to take part in the study; either directly or from a parent/guardian, where appropriate * \[Group A\] Aged 5-10 years inclusive, and determined as healthy by a member of the study team * \[Group B\] Aged 18-25yrs inclusive, and determined as healthy by a member of the study team * \[Group C\] Currently pregnant at any stage of pregnancy, prior to receipt of a tetanus booster vaccine in pregnancy, and determined as healthy by a member of the study team and safe to provide a blood sample * \[Group D\] Adults aged 18-45 years with one or more of the medical conditions that may affect antibody response to vaccination. Exclusion Criteria: * Participants or parents/guardians unwilling or unable to provide informed consent to take part * Unwilling or unable to comply with study procedures * Have a bleeding disorder deemed significant by study doctor * \[Groups A, B and C only\] Any health condition which, in the opinion of a study physician which could 1. mean blood sampling has the potential for harm and/or 2. affect immune response to a vaccine for example known/suspected impairment of immune function (with the exception of Group D)