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Magnetoencephalography (MEG) Pilot Study
Sponsor: University of Florida
Summary
The purpose of this research is to learn more about how the brain works in people with essential tremor, and how it changes after treatment with High-Intensity Focused Ultrasound (HiFU). Essential tremor is a movement disorder that causes shaking, usually in the hands, and can make everyday tasks difficult. HiFU is a treatment that uses focused sound waves to target a small area in the brain involved in tremor. In this study, the investigators aim to understand how this treatment affects the brain's networks by using safe, non-invasive tests such as brain imaging, brain wave recordings, and movement assessments.
Official title: Network Characteristics in Essential Tremor (ET) Patients Undergoing High-Intensity Focused Ultrasound (HiFU): a Magnetoencephalography (MEG) Pilot Study
Key Details
Gender
All
Age Range
50 Years - 84 Years
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2026-02
Completion Date
2027-08
Last Updated
2026-03-03
Healthy Volunteers
No
Conditions
Interventions
MRI and fMRI scans
functional MRI, diffusion tensor imaging, anatomical MRI
MEG
non-invasive electrophysiological technology that provides high temporal and spatial resolution to examine large-scale cortical dynamics.
Sensor-based motor assessments
research-grade wearable sensors equipped with gyroscopes and accelerometers to precisely and accurately quantify patients' tremors. These sensors will be worn on the wrist or finger, capturing data as patients perform standardized tremor assessment tasks, such as spiral drawing task, writing task, commonly used in essential tremor evaluation. Gait and balance assessments will be conducted by synchronizing multiple sensors placed on the upper and lower extremities as well as the midline. Gait and balance data will be collected during tasks such as the 7-meter walk test, 360-degree turn test, and postural sway.
Clinical evaluations
vital signs, health status review, and neurological exam.
Questionnaires and rating scales that
daily functioning, mood, memory, and tremor