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NOT YET RECRUITING
NCT07446400
PHASE1

A Trial to Examine the Interaction of Repinatrabit With Ethinyl Estradiol/Norethindrone, Metformin,Carbamazepine, Rosuvastatin, and Methotrexate When Administered Together

Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.

View on ClinicalTrials.gov

Summary

The purpose of this study is to assess the drug-drug interaction (DDI) of repinatrabit with ethinyl estradiol/norethindrone or norethisterone (EE/NE), metformin, rosuvastatin, carbamazepine, and methotrexate in healthy participants.

Official title: A Phase 1, 4-arm, Open-label, Drug-drug Interaction Trial to Evaluate the Pharmacokinetics of Repinatrabit Oral Tablets When Co-administered With Ethinyl Estradiol/Norethindrone, Metformin, Carbamazepine, Rosuvastatin, and Methotrexate in Healthy Participants

Key Details

Gender

All

Age Range

18 Years - 55 Years

Study Type

INTERVENTIONAL

Enrollment

48

Start Date

2026-03-20

Completion Date

2026-06-12

Last Updated

2026-03-03

Healthy Volunteers

Yes

Interventions

DRUG

Repinatrabit

Oral tablet.

DRUG

EE/NE

Oral tablet.

DRUG

Metformin

Oral tablet.

DRUG

Rosuvastatin

Oral tablet.

DRUG

Methotrexate

Oral tablet.

DRUG

Carbamazepine

Oral tablet.