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A Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist Use
Sponsor: Vanda Pharmaceuticals
Summary
The goal of this study is to measure the effects of using Tradipitant to treat nausea and vomiting induced by GLP-1R agonist use in adults with class I or class II obesity, or adults who are overweight with at least one weight-related condition. The study is placebo-controlled with two treatment arms.
Official title: The Thetis Study: A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Tradipitant on Nausea and Vomiting After GLP-1R Agonist Administration in Healthy Overweight or Obese Volunteers
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
280
Start Date
2026-03-27
Completion Date
2026-12-01
Last Updated
2026-04-20
Healthy Volunteers
Yes
Conditions
Interventions
Tradipitant
Oral Capsule
Placebo
Oral Capsule
Locations (10)
Vanda Investigational Site
Los Angeles, California, United States
Vanda Investigational Site
San Diego, California, United States
Vanda Investigational Site
San Jose, California, United States
Vanda Investigational Site
Tampa, Florida, United States
Vanda Investigational Site
Hamilton, New Jersey, United States
Vanda Investigational Site
New York, New York, United States
Vanda Investigational Site
Syosset, New York, United States
Vanda Investigational Site
Plano, Texas, United States
Vanda Investigational Site
San Antonio, Texas, United States
Vanda Investigational Site
Burke, Virginia, United States