Clinical Research Directory

Inclusion Criteria: * Age 18-50 years old; * meet the Diagnostic and Statistical Manual of Mental Disorders, Fifth edition (DSM-5) diagnostic criteria; * the diagnosis of schizophrenia is confirmed by the Structured Clinical Interview for DSM-5 (SCID-5); * the disease duration does not exceed 8 years; * 1-2 antipsychotic drugs are taken, and the treatment dose of antipsychotic drugs was stable for at least 1 week before enrollment. Mood stabilizers, antidepressants, and excessive benzodiazepines (lorazepam when 2 doses exceeded 2 mg/d) are not allowed; * The type of antipsychotic drugs remains unchanged during treatment, and the dose is adjusted by no more than 25%; * Impaired functioning in daily activities; * The Global Deficit Score (GDS) for the MATRICS Consensus Cognitive Battery (MCCB) reaches 0.5 or above; * Agree to participate in this study and provide written informed consent Exclusion Criteria: * Presence of other psychiatric comorbidities, intellectual disability, obvious mood symptoms, or substance use disorders (other than caffeine and/or tobacco); * with clear drug-induced extrapyramidal reaction; * A history of seizures, meningitis, or encephalitis; * with contraindications to transcranial electrical stimulation; * History of intracranial tumors or surgery; * history of severe head trauma; * have received other regimens of electrical or magnetic therapy in 1 month before enrollment.