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RECRUITING
NCT07447297
NA

Efficacy of Early Rhythm Control Therapy in Patients With Subclinical Atrial Fibrillation

Sponsor: Samsung Medical Center

View on ClinicalTrials.gov

Summary

The goal of this study to find out the efficacy of early rhythm therapy in patients with subclinical atrial fibrillation detected by Cardiac Electronic Implantable Devices. Early rhythm therapy includes antiarrhythmic drug, cardioversion, and catheter ablation. The general control group receives general management without the above atrial fibrillation rhythm control treatment. Researchers will compare early rhythm control groups to general control groups to see if early rhythm therapy works to reduce the atrial fibrillation burden by 50% or more, or decrease the incidence of clinical AF documentation. Participants will: * Randomly allocated to two groups at a 1:1 ratio. * Receive the treatment according to their assigned group. * Visit the clinic once every three months for checkups and tests.

Key Details

Gender

All

Age Range

19 Years - Any

Study Type

INTERVENTIONAL

Enrollment

520

Start Date

2024-01-02

Completion Date

2029-12-31

Last Updated

2026-03-03

Healthy Volunteers

No

Interventions

DRUG

early rhythm control group

flecainide, propafenone, pilsicainide, sotalol, amiodarone, dronedarone and so on

PROCEDURE

cardioversion, catheter ablation

only when clinical atrial fibrillation (if atrial fibrillation continued for more than 30 seconds on a 12-lead electrocardiogram or holter monitoring) is confirmed

OTHER

general control

General management without atrial fibrillation rhythm control treatment.(Observation without additional medication, or heart rate control treatment if necessary) Heart rate control drugs such as beta-blockers, calcium channel blockers (Non-dihydropyridine CCB), and digoxin are used for heart rate control according to the doctor's prescription.

Locations (1)

Samsung Medical Center

Seoul, Seoul, South Korea