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Efficacy of Early Rhythm Control Therapy in Patients With Subclinical Atrial Fibrillation
Sponsor: Samsung Medical Center
Summary
The goal of this study to find out the efficacy of early rhythm therapy in patients with subclinical atrial fibrillation detected by Cardiac Electronic Implantable Devices. Early rhythm therapy includes antiarrhythmic drug, cardioversion, and catheter ablation. The general control group receives general management without the above atrial fibrillation rhythm control treatment. Researchers will compare early rhythm control groups to general control groups to see if early rhythm therapy works to reduce the atrial fibrillation burden by 50% or more, or decrease the incidence of clinical AF documentation. Participants will: * Randomly allocated to two groups at a 1:1 ratio. * Receive the treatment according to their assigned group. * Visit the clinic once every three months for checkups and tests.
Key Details
Gender
All
Age Range
19 Years - Any
Study Type
INTERVENTIONAL
Enrollment
520
Start Date
2024-01-02
Completion Date
2029-12-31
Last Updated
2026-03-03
Healthy Volunteers
No
Interventions
early rhythm control group
flecainide, propafenone, pilsicainide, sotalol, amiodarone, dronedarone and so on
cardioversion, catheter ablation
only when clinical atrial fibrillation (if atrial fibrillation continued for more than 30 seconds on a 12-lead electrocardiogram or holter monitoring) is confirmed
general control
General management without atrial fibrillation rhythm control treatment.(Observation without additional medication, or heart rate control treatment if necessary) Heart rate control drugs such as beta-blockers, calcium channel blockers (Non-dihydropyridine CCB), and digoxin are used for heart rate control according to the doctor's prescription.
Locations (1)
Samsung Medical Center
Seoul, Seoul, South Korea