Clinical Research Directory
Browse clinical research sites, groups, and studies.
Luminal Breast Cancer Cryoablation
Sponsor: Lucía Graña López
Summary
LUBRECA will evaluate the safety and efficacy of cryoablation with liquid nitrogen to treat cT1cN0 luminal breast cancer diagnosed in postmenopausal women
Official title: Cryoablation for the Treatment of Luminal Early Breast Cancer
Key Details
Gender
FEMALE
Age Range
Any - Any
Study Type
INTERVENTIONAL
Enrollment
140
Start Date
2026-03
Completion Date
2028-12
Last Updated
2026-03-09
Healthy Volunteers
No
Interventions
Cryoablation with liquid nitrogen (Prosense® system)
The appropriate cryoprobe (10G or 13G) will be selected depending on the size of the tumor. After injecting local anesthesia, the cryoprobe will be inserted along the longest diameter of the lesion. The tip of the needle will be advanced so that the freezing center is located in the middle of the tumor. Two freezing cycles will be performed, separated by a thawing cycle, all three of the same duration, which depends on the size of the tumor. The goal is a freezing volume with a lethal zone covering the lesion and a safety margin of at least 1 cm. Ultrasound allows real-time monitoring of the expansion of the ice ball during cryoablation. To avoid burning the skin, we will inject warm sterile saline solution when the distance between the ice and the skin surface is less than 0.5 cm
Locations (1)
Hospital Universitario Lucus Augusti
Lugo, Spain