Clinical Research Directory
Browse clinical research sites, groups, and studies.
Can Betamethasone Given After Birth Help Extremely Premature Babies Come Off Breathing Support Safely and Effectively?
Sponsor: Khang Nguyen
Summary
The goal of this study is to determine if giving a steroid medication (specifically, betamethasone) after birth can help extremely premature babies (born before 28 weeks) come off breathing machines safely and reduce their risk of chronic lung disease associated with prematurity. Only babies who meet treatment criteria will receive this medication. Babies who do not meet treatment criteria will not receive medication. The main questions it aims to answer are: * Does betamethasone make it easier for babies to come off a breathing machine? * Does betamethasone cause any harmful side effects on growth or development? All babies in this study will: * Receive standard NICU care, with or without betamethasone * Have their progress, growth, and development followed over time
Official title: Efficacy and Safety of Postnatal Betamethasone for Respiratory Weaning in Extremely Low Gestational Age Neonates (ELGANs) in a Prospective Cohort - Proof of Concept Pilot Study
Key Details
Gender
All
Age Range
Any - 28 Weeks
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2026-04
Completion Date
2029-03
Last Updated
2026-03-03
Healthy Volunteers
No
Interventions
Betamethasone
Infants who meet clinical criteria will receive a 5-day course of postnatal betamethasone: 0.125 mg/kg/dose IM every 24 hours for 3 days then 0.0625 mg/kg/dose IM every 24 hours for 2 days
Locations (1)
Maria Fareri Children's Hospital at Westchester Medical Center
Valhalla, New York, United States