Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Study to Evaluate the Efficacy, Safety, Pharmacodynamics (PD), and Pharmacokinetics (PK) of Selnoflast in Reducing Vascular Inflammation in Participants With Atherosclerosis at Risk for Major Adverse Cardiac Events
Sponsor: Genentech, Inc.
Summary
The main purpose of the study is to evaluate the efficacy of selnoflast compared with placebo in participants with atherosclerosis, at high-risk for major adverse cardiovascular event (MACE), who are currently on standard-of-care (SOC) therapy.
Official title: A Phase IIa, Multicenter, Randomized, Double-blind, Placebo-controlled Study of the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Selnoflast in Reducing Vascular Inflammation in Patients With Atherosclerosis at Risk for Major Adverse Cardiac Events
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
162
Start Date
2026-06-05
Completion Date
2028-02-28
Last Updated
2026-09-29
Healthy Volunteers
No
Conditions
Interventions
Selnoflast
Selnoflast will be administered as per the schedule specified in the respective arm.
Placebo
Placebo will be administered as per the schedule specified in the respective arm.
Locations (25)
Cardiovascular Research Foundation of Southern California
Beverly Hills, California, United States
National Heart Institute
Beverly Hills, California, United States
Amnova Clinical Research
Irvine, California, United States
UCLA Health System - UCLA Cardiovascular Center
Los Angeles, California, United States
NorthBay Clinical Research
Santa Rosa, California, United States
Alliance Clinical West Hills (Focus Clinical Research)
West Hills, California, United States
Yale University School of Medicine Yale-New Haven Hospital (YNHH) - Smilow Cancer Hospital
New Haven, Connecticut, United States
Inpatient Research Clinic (Las Palmas Medical Research Center)
Miami Lakes, Florida, United States
Asha Clinical Research-Munster,Llc
Hammond, Indiana, United States
Profound Research LLC at Cardiology and Vascular Associates - CAVA
Bloomfield Hills, Michigan, United States
Profound Research LLC at Millenium Cardiology
Farmington Hills, Michigan, United States
Ahmed Arif Medical Research Center (AA MRC LLC )
Flint, Michigan, United States
University of Minnesota
Minneapolis, Minnesota, United States
Washington University, School of Medicine
St Louis, Missouri, United States
University of Nebraska Medical Center
Omaha, Nebraska, United States
DiGiovanna Inst for Med Ed&Res
North Massapequa, New York, United States
UNC Heart & Vascular
Chapel Hill, North Carolina, United States
Preferred Primary Care Physicians, Inc
Pittsburgh, Pennsylvania, United States
Vanderbilt University School of Medicine (VUSM) - Vanderbilt Translational and Clinical Cardiovascular Research Center (VTRACC)
Nashville, Tennessee, United States
Southwest Family Medicine Associates
Dallas, Texas, United States
East Texas Cardiology PA
Houston, Texas, United States
Cardiovascular Specialists of Willowbrook
Houston, Texas, United States
UT Health San Antonio
San Antonio, Texas, United States
Eastside Research Associates, LLC dba Era Health Research
Redmond, Washington, United States
Cardio Health Clinical Trials
Hamilton, Ontario, Canada