Clinical Research Directory
Browse clinical research sites, groups, and studies.
Evaluation of the Efficacy of Oral Tranexamic Acid and Glutathione-assisted Microneedling in Treatment of Melasma
Sponsor: Assiut University
Summary
In this study, the investigators evaluate the potential efficacy of TXA alone and microneedling assisted with glutathione alone versus combination of oral tranexamic acid and glutathione-assisted microneedling in the treatment of melasma
Official title: Evaluation of the Efficacy and Safety of Oral Tranexamic Acid Combined With Glutathione-assisted Microneedling Versus Each Therapy Alone in the Treatment of Melasma
Key Details
Gender
FEMALE
Age Range
18 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
42
Start Date
2026-02
Completion Date
2027-04
Last Updated
2026-03-04
Healthy Volunteers
No
Conditions
Interventions
microneedling
with one ml of topical glutathione will be done in group A and B, three consecutive sessions, will be performed by derma pen with 36 needles head, will adjusted 1.5 mm needle length and will moved on stretched skin in four directions several times till erythema and pinpoint developed before and after topical application of GTH.
Oral tranexamic acid
The patient will take oral tranexamic acid 250mg twice daily for 3 months
Glutathione
investigators will use topical GSH solution in assist with microneedling to treat melasma