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Comprehensive Invasive Physiological Evaluation of Obstructive Coronary Artery Disease
Sponsor: UMC Utrecht
Summary
The goal of this clinical trial is to test whether adding coronary function testing and starting targeted medical treatment for identified vasomotor disorders will also improve angina symptoms and quality of life in patients with obstructive coronary artery disease who undergo percutaneous coronary intervention. The main question it aims to answer is: Does performing coronary function testing in patients with obstructive coronary artery disease who undergo percutaneous coronary intervention lead to better relieve of angina symptoms and improvement in quality of life? Researchers will compare this group undergoing coronary function testing with a control group who will solely undergo percutaneous coronary intervention. Participants will: * Undergo percutaneous coronary intervention and coronary function testing in the intervention arm * Undergo percutaneous coronary intervention in the control arm
Official title: Inclusive Invasive Physiological Assessment in Angina Syndromes - Obstructive Coronary Artery Disease
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
450
Start Date
2026-03-01
Completion Date
2029-03-01
Last Updated
2026-03-04
Healthy Volunteers
No
Conditions
Interventions
Coronary function testing
Coronary function testing to test for coronary microvascular dysfunction and coronary vasospasm
Percutaneous coronary intervention
Percutaneous coronary intervention performed according to local practice standards and guidelines