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NOT YET RECRUITING
NCT07450534

The Practicality and Utility of Measured vs Estimated GFR in adCKD

Sponsor: Manchester University NHS Foundation Trust

View on ClinicalTrials.gov

Summary

The goal of this observational study is to assess if new ways of measuring kidney function can better predict when individuals will become symptomatic due to kidney failure, and whether residual kidney function can be accurately measured in those already on dialysis. The main questions the study is trying to answer is whether measuring kidney function by clearance of iohexol is comparable to the current standard of care methods. In addition to routine care, participants will: * undergo a brief clinical assessment * be given an injection of iohexol and asked to perform 4 finger prick blood tests over 24 hours, recording the time of each sample. Samples will be returned in person or posted back * be asked to complete a questionnaire on their experience

Official title: The Practicality & Utility of Estimated vs Measured Renal Function in Advanced Kidney Disease, Whether Treated With Dialysis or Not: Can Better Techniques be Used to Predict the Onset of the Uraemic Syndrome and Guide Dialysis Requirements

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

150

Start Date

2026-02

Completion Date

2027-02

Last Updated

2026-03-04

Healthy Volunteers

No

Interventions

DIAGNOSTIC_TEST

Iohexol Inj 300 MG/ML Diagnostic aid/agent used to measure glomerular filtration rate (GFR)

Injection of 3235mg iohexol (equivalent to 5ml Omnipaque 300) followed by serial dried blood spot testing over 24 hours to be measured for iohexol concentration and used to calculate clearance.

Locations (1)

Manchester Royal infirmary

Manchester, United Kingdom