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The Impact of Saline Temperature and Local Anesthetic Adjuvants on Postoperative Shoulder Pain and Inflammatory Marker Levels Following Laparoscopic Cholecystectomy
Sponsor: Alexandria University
Summary
Laparoscopic cholecystectomy has become the gold standard for the operative treatment of gallbladder disease due to its minimally invasive nature and improved patient outcomes. However, postoperative pain remains a significant concern following this procedure, affecting patient comfort, recovery, potential for same day discharge and overall satisfaction. However, visceral pain, port-site pain, and referred shoulder pain are occasionally reported in laparoscopic cholecystectomy patients . Postoperative shoulder pain is a common complication following laparoscopic cholecystectomy, often attributed to diaphragmatic irritation.
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
216
Start Date
2026-02-01
Completion Date
2027-08-01
Last Updated
2026-03-17
Healthy Volunteers
No
Interventions
Room-temperature saline (25-30 ml/kg ) irrigation without local anesthetic.
Room-temperature saline (25-30 ml/kg ) irrigation without local anesthetic.
Room-temperature saline (25-30 ml/kg l) with local anesthetic ( 0.25% bupivacaine according to body weight).
Room-temperature saline (25-30 ml/kg l) with local anesthetic ( 0.25% bupivacaine according to body weight).
Warm saline (37°C, 25-30 ml/kg ) irrigation without local anesthetic.
Warm saline (37°C, 25-30 ml/kg ) irrigation without local anesthetic.
Warm saline (37°C, 25-30 ml/kg) with local anesthetic (0.25% bupivacaine).
Warm saline (37°C, 25-30 ml/kg) with local anesthetic (0.25% bupivacaine).
No saline irrigation.
No saline irrigation.
No saline irrigation but with local anesthetic (local anesthetic instillation at trocar sites).
No saline irrigation but with local anesthetic (local anesthetic instillation at trocar sites).
Locations (1)
medical research institute , Alexandrria university
Alexandria, Egypt