Clinical Research Directory
Browse clinical research sites, groups, and studies.
Diabetes In Asians at Risk in Youth
Sponsor: Singapore General Hospital
Summary
This observational study aims to develop novel contemporary risk factor tools for detecting young onset diabetes (under 40y) in young Asians in Singapore. The investigators aim to recruit 3000 people not currently known to have diabetes, selected across age and Body Mass Index categories, and perform formal diagnostic tests for diabetes (oral glucose tolerance test and HbA1c). The participants will also undergo continuous glucose monitoring sensor, keep a food diary, and undergo body composition analysis using bioimpedance analysis, handgrip measurements for muscle strength, and sociobehavioural profiling through download of a curated list of social media interactions. The participants will also have a blood sample retrieved and stored for subsequent comparison between people with normal glucose versus abnormal glucose levels. The whole group will also have another blood sample stored for whole gene analysis.
Official title: Diabetes in Asians at Risk in Youth
Key Details
Gender
All
Age Range
21 Years - 39 Years
Study Type
OBSERVATIONAL
Enrollment
3000
Start Date
2026-03-18
Completion Date
2029-01-02
Last Updated
2026-03-05
Healthy Volunteers
Yes
Interventions
Oral glucose tolerance test and HbA1c
Following overnight fasting for 8 hours
Anthropometric measurements
Body Mass Index, Waist-Hip ratio, Blood pressure
Body impedance Analysis
Body composition analysis
Handgrip measurement
Handgrip strength measured using Jamar Dynanometer
Continuous glucose monitoring
Use of Retrospective continuous glucose monitoring sensor (Freestyle Libre Pro IQ)
Food diary recording over days 2 and 3 of continuous glucose monitoring
Including written food records and photographs for all food and drink intake
Survey
Retrieval of sociodemographic details, family history of diabetes and comorbid conditions, information on dietary intake, physical activity levels, and health seeking behaviour. This includes average daily step count for 7/30 days.
Skin reaction information
Form to feedback on any sensor skin reactions
Download of social media data
This will involve a highly curated list of information to be retrieved from Facebook, Instagram and TikTok to enable AI-led sociobehavioural profiling. This will not retrieve any information on posts, photos, likes, comments, reactions or any item that will express intent.
Whole genome sequencing
Whole blood sample will be retrieved and stored before being sent for whole genome sequencing at a later stage.