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Reference Measurements of the Neuronal Integration Window and Anatomical and Functional MRI (Magnetic Resonance Imaging)
Sponsor: University Hospital, Strasbourg, France
Summary
Our studies on MRI (Magnetic resonance imaging) biomarkers in neuropsychiatric disorders rely on reference data from control subjects which are dependent from our scanner. Due to the upcoming replacement of our MR scanner, the investigators need to 'recalibrate' our current database by acquiring the same data on both the old and the new device from a small group of controls (n = 36 to 40). This will be combined with measures of cortical excitability using robotized TMS (transcranial magnetic stimulation) that will be combined to MRI biomarkers in forthcoming studies. Therefore, the primary objective of this biomedical trial is to collect MRI and physiological measurements in normal subjects whose characteristics match to our study populations.
Official title: Reference Measurements of the Neuronal Integration Window and Anatomical and Functional MRI
Key Details
Gender
All
Age Range
18 Years - 86 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2023-05-17
Completion Date
2026-12-31
Last Updated
2026-03-05
Healthy Volunteers
Yes
Conditions
Interventions
MRI (Magnetic Resonance Imaging)
2 MRI sessions on 3 Tesla Vério Siemens scanner at V1, separated by minimum one week Anatomical and functional measures: * 3 ASL-fMRI with ET = 9.7 ms, 3 ASL-fMRI with ET = 21 ms during various tasks. * Multiparametric quantitative measures (NODDI, R1, R2, R2\*, magnetic susceptibility, macromolecular proton fraction). * 3DT1 and 3D FLAIR.
TMS (Transcranial Magnetic Stimulation)
1 session at visit V2. Intracortical inhibition, neuronal integration and window of simultaneity Mapping of passive and active motor evoked potential MEP using dedicated robotic device under the control of neuronavigation. + cortical and trans-cortical silence period
MRI (Magnetic Resonance Imaging)
2 MRI sessions on 3 Tesla Vida scanner at V3, separated by minimum one week. 2 MRI sessions on "new" MR-scanner Anatomical and functional measures: * 3 ASL-fMRI with ET = 9.7 ms, 3 ASL-fMRI with ET = 21 ms during various tasks. * Multiparametric quantitative measures (NODDI, R1, R2, R2\*, magnetic susceptibility, macromolecular proton fraction). * 3DT1 and 3D FLAIR.
Locations (1)
Les Hôpitaux Universitaires
Strasbourg, Bas-Rhin, France