Clinical Research Directory

Inclusion Criteria: * Age ≥ 18 years. * Implanted cardiovascular device (prosthetic valve, TAVI, CIED, vascular graft/endograft). * For infected cohorts: patients studied by FDG-PET with definitive diagnosis of CVDI based on multidisciplinary evaluation. * For control group: no clinical suspicion of infection at time of inclusion. * Written Informed consent provided (prospective cohort and control group). * Women of child-bearing potential must have a negative pregnancy test in serum or urine before the inclusion in the study and agree to use highly effective contraceptive methods during the study. Highly effective contraceptive methods will include: intrauterine device, bilateral tubal occlusion, vasectomized partner and sexual abstinence (only if refraining from heterosexual intercourse during the period of twelve months of duration of the study). Exclusion Criteria: * Inability to undergo FDG-PET due to contraindications (e.g., allergies, claustrophobia). * Pregnancy or breastfeeding. * Incomplete clinical data or lack of access to imaging studies. * Refusal or withdrawal of informed consent (for control and prospective cohort).