Clinical Research Directory
Browse clinical research sites, groups, and studies.
Study to Evaluate Switching to Brelovitug for the Treatment of CHD in Participants Receiving Bulevirtide
Sponsor: Mirum Pharmaceuticals, Inc.
Summary
This is a Phase 2b/3, randomized, open-label, multicenter trial evaluating the efficacy and safety of switching from bulevirtide to brelovitug for the treatment of chronic hepatitis Delta infection (CHD).
Official title: A Phase 2b/3, Open-Label, Multicenter Trial Evaluating the Efficacy and Safety of Switching to Brelovitug for the Treatment of Chronic Hepatitis Delta Infection in Participants Receiving Bulevirtide (AZURE-3)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2026-02-26
Completion Date
2029-03-30
Last Updated
2026-05-01
Healthy Volunteers
No
Conditions
Interventions
Brelovitug (BJT-778)
Brelovitug (BJT-778), 300 mg administered subcutaneously once weekly for 96 weeks.
Bulevirtide
Bulevirtide - once daily. Brelovitug (BJT-778) - 300 mg once weekly for 72 weeks following bulevirtide.
Locations (22)
Medical University of Graz
Graz, Austria
Fakultni Nemocnice Brno (University Hospital Brno)
Brno, Czechia
Klin Med Ltd. (KLIN MED s.r.o.)
Prague, Czechia
Institut klinicke a experimentalni mediciny- IKEM (Institute for Clinical and Experimental Medicine)
Prague, Czechia
CHU de Bordeaux
Bordeaux, France
Hospital Beaujon
Clichy, France
CHU Toulouse Hospital Rangueil, Toulouse
Toulouse, France
University Hospital of Dusseldorf
Düsseldorf, Germany
Goethe University Frankfurt
Frankfurt, Germany
Medizinische Hochschule Hannover
Hanover, Germany
Universitatsmedizin Rostock
Rostock, Germany
Centrul Medical Unirea S.R.L
Iași, Lasi, Romania
Clinical Hospital for Infectious and Tropical Diseases Dr. Victor Babes
Bucharest, Romania
National Institute Of Infectious Diseases Prof. Dr. Matei Bals
Bucharest, Romania
Spitalul Clinic de Boli Infectioase Constanta
Constanța, Romania
Vall d'Hebron Hospital
Barcelona, Spain
Hospital Clinic I Provincial De Barcelona
Barcelona, Spain
Castle Hill Hospital
Cottingham, Yorkshire, United Kingdom
Barts Health NHS Trust
London, United Kingdom
King's College Hospital NHS Foundation Trust
London, United Kingdom
Chelsea and Westminster Hospital
London, United Kingdom
Manchester University Nhs Foundation Trust
Manchester, United Kingdom