All Participants Major Inclusion Criteria:
1. Adult males and females, 18 to 75 years of age (inclusive)
2. Body mass index (BMI) ≥18.0 and \<40.0 kg/m2 with a minimum body weight of 45 kg
3. Use of adequate contraception for both males and females. Female volunteers must be of nonchildbearing potential or if of childbearing potential, must have a negative pregnancy test.
All Participants Major Exclusion Criteria:
1. Have received a PD-1 agonist, immune checkpoint agonist, immune checkpoint inhibitor, anti-CD19 or anti-CD20 agents, cell therapy, B cell modulating agents, alkylating agents, or any other immune cell depleting therapy.
2. Have received azathioprine, cyclosporine, mycophenolate mofetil, or tacrolimus within 4 weeks
3. Unable or unwilling to discontinue a prohibited medication
4. Presence of clinically relevant immunosuppression
5. Current infection or history of severe infection
6. Any history of malignant disease, with some exceptions
Major inclusion/exclusion for each autoimmune or immune-mediated disease:
For RA:
1. Confirmed diagnosis of moderate to severe active RA by the American College of Rheumatology (ACR) 2010/European League Against Rheumatism (EULAR) criteria for at least 3 months prior to the Screening 1 visit, and:
1. ≥6 swollen joint count based on 66 joint count
2. ≥6 tender joint count based on 68 joint count
3. Seropositive for RF and/or ACPA
4. Elevated hsCRP ≥1.2 times greater than the ULN
5. Does not have Class IV RA according to ACR revised criteria
2. Inadequate response to, or loss of response, or intolerance to:
1. \>1 conventional synthetic DMARD after 3 months of therapy OR
2. \>1 biologic DMARD/targeted synthetic DMARD after 3 months of therapy
3. Has not failed 3 or more bDMARDs and/or tsDMARDs
For PsA:
1. Confirmed diagnosis of adult-onset PsA classified by the Classification Criteria for Psoriatic Arthritis (CASPAR) for at least 3 months prior to the Screening 1 visit, with all of the following:
1. Active PsO defined by at least 1 psoriasis lesion
2. Active disease defined by \>3 swollen joints and \>3 tender joints using the 76/78 swollen and tender joint count
2. Received standard doses of NSAIDs for \>4 weeks or csDMARDs for \>3 months and has been on a stable dose for \>8 weeks, or participant has intolerance to NSAIDs or DMARDs
3. Participants may be TNF inhibitor therapy naïve or may have received 1 prior TNF inhibitor
4. Has not had inadequate response or intolerance to 2 or more bDMARDs or csDMARDs
For PsO:
1. Confirmed diagnosis of moderate to severe plaque PsO for at least 6 months, with all of the following:
1. Psoriasis Area and Severity Index (PASI) \>12 points
2. Static Physician's Global Assessment (sPGA) \>3 points
3. Body surface area (BSA) of PsO involvement \>10%
2. Cannot have a clinically significant flare within 12 weeks
3. Does not have history of erythrodermic psoriasis, generalized or localized pustular psoriasis, predominantly guttate psoriasis, or medication-induced or medication-exacerbated psoriasis
4. Has not had inadequate response to more than 2 prior bDMARDs
For CLE (with or without systemic manifestations):
1. Histologically confirmed diagnosis of CLE with or without systemic manifestations for at least 6 months
2. Has active skin manifestations as measured by CLASI-A \>10 or CLASI-A \>8, if there is no alopecia or mucous membrane lesions
3. Participant must have an active CLE lesion despite an adequate trial of antimalarial treatment for at least 6 months.
4. Cannot have active lupus nephritis or moderate-to-severe or chronic kidney disease with eGFR \<45 mL/min/1.73m2
5. Cannot have active neuropsychiatric SLE
For AD:
1. Confirmed diagnosis of AD as defined by the American Academy of Dermatology: Guidelines of Care for the Management of Atopic Dermatitis for at least 12 months
1. Eczema Area and Severity Index (EASI) \>16
2. Validated Investigator Global Assessment (vIGA-AD) \>3
3. BSA of AD involvement \>10%
4. PP-NRS) \>4 (average of daily scores) during the 7 days prior to dosing
2. Inadequate response to existing topical medications within 6 months or has a history of intolerance to topical therapy as defined by at least 1 of the following:
1. Inability to achieve good disease control after use TCS for at least 4 weeks
2. Documented history of clinically significant AEs with the use of TCS
3. Failed systemic therapies intended to treat AD within 6 months
Additional inclusion/exclusion criteria will apply.
