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Assessment of the Locally Administrated Vitamin D3 and Corticision Efficacy on Orthodontic Canine Retraction
Sponsor: Al-Azhar University
Summary
To study the effect vitamin D effect on orthodontic tooth movement when used in combination with coticision technique, independent t test or an equivalent non-parametric test will be used for comparison. According to a previous study by (S. T. Varughese, et al. (2019) , "Effect of vitamin D on canine distalization and alveolar bone density using multi-slice spiral CT: a randomized controlled trial
Official title: Assessment of the Locally Administrated Vitamin D3 and Corticision Efficacy on Orthodontic Canine Retraction: A Prospective Clinical Study
Key Details
Gender
All
Age Range
13 Years - 20 Years
Study Type
INTERVENTIONAL
Enrollment
16
Start Date
2025-08-01
Completion Date
2027-08-01
Last Updated
2026-03-06
Healthy Volunteers
Yes
Conditions
Interventions
patients will receive local application of vitamin D3 combined with corticision
Administration of the Solution at eexperimental side: One milliliter of was injected into the buccal vestibule at the level of the distal margin of the root of the canine. One milliliter of (ONE ALPHA 2 MCG / ML 10 AMP 0.5 ML Leo Pharmaceutical products Ballerup - Denmark. Imported by: Egyptian Company for Drug Trading) was injected four times during treatment on the the beginning (T0), 4 weeks (T1), 8 weeks (T2), and 12 weeks (T3) of canine retraction on both sides according to Varughese, et al. " Participants were evaluated from the beginning (T0), 4 weeks (T1), 8 weeks (T2), and 12 weeks (T3) of canine distalization. At these appointments, impressions were made to obtain the study models. Multi-slice spiral computed tomography scans were taken at T0 and T3 to measure the changes in bone density following canine distalization. The primary outcome was to evaluate the rate and total amount of canine distalization as well as anchorage loss in the maxillary arch. All study measurements
Locations (1)
Orthodontic Outpatient Clinic, Faculty of Dental Medicine, Al-Azhar University
Cairo, Cairo Governorate, Egypt