Clinical Research Directory

Main Inclusion Criteria: * Participants suitable veins for cannulation or repeated venipuncture. * All females must have a negative pregnancy test at the Screening Visit and on admission to the Clinical Unit. * Female participants: 1. of childbearing potential must not be lactating and if heterosexually active must agree to use an approved method of highly effective contraception, to avoid pregnancy. 2. of non-childbearing potential must be confirmed at the Screening Visit. * Male participants: 1. Sexually active fertile male participants with partners of childbearing potential must adhere to the contraception methods. 2. Additional contraception must be used for the sexual partners of male study participants throughout the clinical study. * Have a Body Mass Index (BMI) of ≥ 23 kg/m2 but not exceeding 35 kg/m2 inclusive (at the time of Screening) and weigh at least 60 kg. Main Exclusion Criteria: * History of any clinically important disease or disorder which, may either put the participant at risk because of participation in the study, or influence the results or the participant's ability to participate in the study. * Any clinically significant illness, medical/surgical procedure, or trauma * Participants who have a special dietary requirement and who are unable/unwilling to follow a uniform diet. * Participants positive for anti- hepatitis B core antibody (anti-HBc) or anti-hepatitis C Virus Antibody (anti-HCV). * Participants who are on or are planning to undertake a weight loss program during the study period. * Abnormal vital signs, after 10 minutes supine rest, at Screening and/or admission to the Clinical Unit. * Positive screen for drugs of abuse, or alcohol or cotinine (nicotine). * Any laboratory values with the deviations specified in protocol and clinically important abnormalities in clinical chemistry, hematology, or urinalysis results.