Clinical Research Directory

* Inclusion Criteria: 1. Age ≥ 18 years; 2. Clinically diagnosed with acute ischemic stroke; 3. RACE score ≥ 4 points upon hospital arrival; 4. Time from symptom onset/last known normal to hospital arrival ≤ 6 hours; 5. Pre-stroke mRS score 0-1; 6. Informed consent signed by the patient or their legal representative. * Exclusion Criteria: 1. Hemorrhagic stroke diagnosed by cranial CT or MRI during this current episode; 2. Uncontrolled hypertension with medication (defined as systolic blood pressure \> 185 mmHg or diastolic blood pressure \> 110 mmHg) (Note: Patients may be included if blood pressure can be successfully reduced and maintained at an acceptable level with medication); 3. Known hereditary or acquired bleeding tendency, such as coagulation factor deficiency, or INR \> 3.0 or PT \> 3 times the normal range after anticoagulant therapy (Patients without a history of coagulation dysfunction or suspected coagulation dysfunction do not need to wait for laboratory results of INR or prothrombin time before enrollment); 4. Received heparin, low-molecular-weight heparin (e.g., dalteparin sodium), or thrombin inhibitors (e.g., bivalirudin, argatroban) within 24 hours with a history of coagulation disorders; 5. Baseline laboratory values: blood glucose \< 50 mg/dl (2.78 mmol/L) or \> 400 mg/dl (22.20 mmol/L), hemoglobin count \< 7 mmol/l (11.28 g/dl); platelet count \< 50,000/μl; 6. Patients with renal failure, defined as serum creatinine \> 3.0 mg/dl (264 μmol/l) (Note: Patients undergoing dialysis can be included regardless of serum creatinine level); 7. Cerebral embolism caused by septic emboli or bacterial endocarditis; 8. History of stroke within the past 3 months; 9. Seizure at stroke onset leading to diagnostic confusion and difficulty in accurate baseline RACE assessment; 10. History of previous neuropsychiatric disorders that make accurate neurological function assessment difficult, such as dementia patients taking cholinesterase inhibitors; 11. Diagnosis of cerebral vasculitis, brain tumor, or traumatic brain injury within the past 3 months; 12. Major organ surgery or biopsy within 30 days; 13. Active bleeding or recent bleeding within 30 days; 14. History of previous intracranial stent implantation; 15. History of severe contrast agent allergy (non-rash allergy); 16. Patients with other contraindications to reperfusion therapy or who refuse reperfusion therapy; 17. Life expectancy less than 180 days; 18. Lactating women or women with positive pregnancy test on admission; 19. Patients who refuse or cannot cooperate with follow-up.