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RECRUITING
NCT07457736
EARLY_PHASE1

Evaluation of [18F]GATT-44 for Positron Emission Tomography Imaging of the GABA Transporter-1

Sponsor: Yale University

View on ClinicalTrials.gov

Summary

Evaluate \[18F\]GATT-44 (aka \[18F\]GAT44), to characterize its pharmacokinetic, metabolic, and in vivo binding profile, and assess the reproducibility of kinetic and binding parameters. Assess specific binding levels of \[18F\]GATT-44 by conducting a test-block study in humans. Estimate human dosimetry of \[18F\]GATT-44 by performing whole-body imaging studies.

Key Details

Gender

All

Age Range

18 Years - 60 Years

Study Type

INTERVENTIONAL

Enrollment

32

Start Date

2026-04

Completion Date

2030-01

Last Updated

2026-04-06

Healthy Volunteers

Yes

Interventions

DRUG

[ 18F]GATT-44

First in human radiotracer being evaluated in this study.

Locations (1)

Yale University PET Center

New Haven, Connecticut, United States