Clinical Research Directory

Inclusion Criteria: * 1\) 18-65 Years. * 2\) Drug Resistant Epilepsy. * 3\) Motor Epilepsy - defined as: 1. Epilepsy diagnosis meeting ILAE criteria 2. Motor Epilepsy defined as including one or more of: i. Tonic, Clonic, or Tonic-Clonic activity; ii. Myoclonic Jerks; iii.Epileptic Spasms; iv.Focal Motor Seizures (identified primary lesion will be in motor functional area, such as primary motor cortex (BA4), pre-motor cortex (BA6), Central Posterior Gyrus (BA1-3), or other motor region); v.Motor activity not secondary to non-motor seizure. c.Clinical or Electrographic corroboration of at least one of: i.Video-EEG confirmation of motor seizure semiology; ii.Interictal or ictal EEG findings consistent with epileptic motor network involvement; iii.Consistent clinical description by trained cliniciants. * 4\) \>3 Focal or Generalized seizures / month with an inter-seizure interval no great than 30 days. * 5\) Subject or caregiver is able to provide epileptic seizure diary within 90 days prior to the surgery. * 6\) Voluntarily participate in the trial, sign the informed consent form, and be willing to comply with study requirements, including follow-ups. Exclusion Criteria: * 1\) Non Motor Epilepsy. * 2\) Previous diagnosis of psychogenic/non-epileptic seizures. * 3\) Brain lesion resection or ablation surgery performed less than 6 months. * 4\) Implanted Vagus nerve stimulation (VNS) or responsive neurostimulation (RNS) devices recommended neither stimulation off the device at least 6 months nor remove the device.