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Extended Interval Dosing of Gentamicin in Neonates
Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Summary
A previous pharmacy residency project was done 20 years ago looking at the best dosing for the antibiotic gentamicin for babies up to 7 days old. This study showed that giving the dose less often leads to better drug concentrations than giving the dose more often. Our gentamicin dosing at the Children's Hospital at London Health Sciences Centre is based on the better dosing from the study. This dosing is gentamicin 3 mg/kg every 24 hours for babies less than 35 weeks gestational age and 3.5 mg/kg every 24 hours for babies at least 35 weeks gestational age. These results were never published. Different dosing is used at different hospitals. It is important that we check that our gentamicin dosing is still reaching safe and effective drug concentrations in the current study. The study will look at the gentamicin drug concentrations of babies up to 7 days old, including premature and term babies. We will also confirm if the babies have kidney or hearing damage from gentamicin. We will compare the gentamicin drug concentrations from this study to the past data to see if the dosing is still the best. The results can help form a guideline for the Children's Hospital and surrounding hospitals.
Official title: Extended Interval Dosing of Gentamicin in Neonates to Achieve Target Drug Concentrations
Key Details
Gender
All
Age Range
0 Days - 7 Days
Study Type
OBSERVATIONAL
Enrollment
42
Start Date
2026-03
Completion Date
2026-05
Last Updated
2026-03-10
Healthy Volunteers
No
Conditions
Interventions
Standard of care administration of gentamicin dosed at 3 mg/kg every 24 hours
No interventions will be made to the neonates. Standard of care will be followed with empiric gentamicin and levels ordered for the neonates at the discretion of the medical team.
Standard of care administration of gentamicin dosed at 3.5 mg/kg every 24 hours
No interventions will be made to the neonates. Standard of care will be followed with empiric gentamicin and levels ordered for the neonates at the discretion of the medical team.
Locations (1)
Children's Hospital: London Health Sciences Centre
London, Ontario, Canada