Clinical Research Directory

Inclusion Criteria: * Age≥18 years old; * Patients presenting with symptoms or signs suggestive of acute large vessel occlusion (LVO) stroke； * Randomization within 6 hours of symptom onset； * Baseline NIHSS score ≥10 points prior to randomization; * Pre-stroke modified Rankin Scale (mRS) score ≤2; * Written informed consent from patients or their legally authorized representatives. Exclusion Criteria: * Refusal of endovascular treatment； * Allergy to contrast agents; * Clinical symptoms or signs suggestive of intracranial hemorrhage (e.g., severe headache, seizures, or signs of increased intracranial pressure); * Transferred patients (e.g., from centers without thrombectomy capability); * Seizure at stroke onset, postictal paralysis, or inability or unwillingness to cooperate due to epilepsy or other neurological or psychiatric disorders; * Clinically unstable conditions requiring urgent life-support treatment; * Other standard contraindications to endovascular treatment; * Any terminal illness such that the patient would not be expected to survive more than 1 year; * Pregnant women, nursing mothers, or women with a positive pregnancy test at admission; * Unlikely to adhere to the trial protocol or follow-up; * Any condition that, in the judgment of the investigator could impose hazards to the patient if study therapy is initiated or affect the participation of the patient in the study; * Participation in other interventional clinical trials within the previous 3 months.