Clinical Research Directory

Inclusion Criteria: 1. Males and females of all races and ethnicity 2. \>18 to 50 years 3. Healthy based on medical history 4. Scheduled for elective extraction of one or more partially or fully impacted mandibular third molars 5. Able to understand and sign the informed consent form 6. Willing and able to comply with all study procedures 7. Available for the duration of the study 8. Able to understand the directions for data gathering instruments Exclusion Criteria: 1. Children (\< 18 years of age) 2. T-score ≥ 60 in any of the three PROMIS measures (i.e., sleep, anxiety, and depression) 3. Other concomitant surgery being performed in addition to third molar extraction 4. History of gastrointestinal bleeding and/or peptic ulcer, renal disease (excluding kidney stones), hepatic disease, bleeding disorder, respiratory depression 5. History of respiratory depression with opioids or other anesthetic drugs that required postoperative ventilatory support or naloxone 6. Active or untreated asthma 7. Known allergy to ibuprofen, acetaminophen, oxycodone, hydrocodone, and/or anesthesia 8. Currently taking CYP3A4 inhibitors, azole-antifungal agents, protease inhibitors, or CNS depressants 9. Consumes three or more alcoholic drinks per day 10. Active alcoholism or illicit drug abuse (defined as daily use of illicit drugs) 11. History of substance or alcohol abuse 12. History of substance or alcohol abuse in a first-degree relative 13. No more than one opioid prescription filled within the past 12 months (self-report and PDMP) 14. Pregnant or lactating women Sex, race, and ethnicity will not be used as exclusion criteria.