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Aqueous Humor and Ocular Tissue Analysis in Glaucoma and Cataract
Sponsor: Military Institute od Medicine National Research Institute
Summary
This observational study will compare proteomic and elemental profiles of aqueous humor and ocular tissues in patients with primary open-angle glaucoma (POAG) and cataract versus cataract controls without glaucoma. Samples collected during standard surgery will be analyzed using LC-MS/MS and ICP-MS. The goal is to identify glaucoma-associated molecular patterns with potential diagnostic or prognostic relevance.
Official title: Integrated Chemical and Proteomic Analysis of Aqueous Humor and Ocular Tissues in Glaucoma and Cataract Patients
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2026-01-21
Completion Date
2027-11-30
Last Updated
2026-03-10
Healthy Volunteers
No
Interventions
Phacoemulsification With Intraocular Lens Implantation and Deep Sclerectomy
Standard-of-care combined cataract surgery (phacoemulsification with intraocular lens implantation) performed together with deep sclerectomy for glaucoma management. Intraoperative collection of aqueous humor and routinely removed ocular tissues (such as sclera and anterior lens capsule) is performed for research analyses.
Phacoemulsification With Intraocular Lens Implantation
Standard-of-care cataract surgery (phacoemulsification with intraocular lens implantation). Intraoperative collection of aqueous humor and routinely removed ocular tissue (anterior lens capsule) is performed for research analyses.
Locations (2)
Military Institute of Medicine - National Research Institute
Warsaw, Poland
University of Warsaw
Warsaw, Poland