Clinical Research Directory
Browse clinical research sites, groups, and studies.
Effect Clomiphene vs Clomiphene Along With Pioglitazone on Ovarian Stimulation Rate
Sponsor: PAEC General Hospital, Islamabad
Summary
Women who meet the study requirements will be enrolled and randomly assigned by a computer system to receive either pioglitazone 30 mg daily or a placebo starting from the second day of their menstrual period for the same duration. All participants will also take clomiphene citrate 150 mg daily from day 3 to day 7 of the menstrual cycle. A transvaginal ultrasound will be performed on day 10 of the menstrual cycle to assess the growth of ovarian follicles, and the number of mature follicles (16-24 mm) will be recorded. If at least one mature follicle measuring 16-24 mm is present and the endometrial thickness is at least 7 mm, an injection of human chorionic gonadotropin (hCG) will be given to trigger ovulation, followed by an intrauterine insemination (IUI) procedure. Participants will be followed until the end of the menstrual cycle, and if the menstrual period is delayed by 5 days, a blood test for β-hCG will be performed to confirm pregnancy. Any side effects during the treatment period, such as swelling, fluid retention, blurred vision, or weight gain, will be recorded.
Official title: Comparison of Clomiphene Citrate vs Clomiphene Citrate in Combination With Pioglitazone in Terms of Ovarian Stimulation and Pregnancy Rates Among Infertile Women Suffering From Polycystic Ovarian Syndrome
Key Details
Gender
FEMALE
Age Range
18 Years - 38 Years
Study Type
INTERVENTIONAL
Enrollment
62
Start Date
2026-03-01
Completion Date
2026-06-01
Last Updated
2026-03-10
Healthy Volunteers
Yes
Conditions
Interventions
Clomiphene Citrate.
150 mg clomiphene citrate will be administered at third and seventh days of the menstrual cycle
Pioglitazone (PIO) + Clomiphene citrate
Patients will receive 30 mg pioglitazone daily; from the second day of menstruation along with 150 mg clomiphene citrate will be administered to both groups between the third and seventh days of the menstrual cycle.
Locations (1)
Pakistan Atomic Energy Commission Hospital
Islamabad, Federal, Pakistan