Clinical Research Directory

Inclusion Criteria: * Age ≥ 40 years old; * Patients with severe stenosis of the internal carotid artery; * Planned for carotid artery stent; * Modified Rankin Scale score ≤ 2; * The subject has adequate temporal bone windows to undergo TCD, and the blood flow signal of the middle cerebral artery is detectable.; * Signed informed consent by patient or their legally authorized representative. Exclusion Criteria: * Comorbid conditions with severe infections or severe diseases of the liver, kidney, hematopoietic system, endocrine system, etc.; * Occurrence of intracranial hemorrhage (cerebral parenchymal hemorrhage, subarachnoid hemorrhage, subdural/epidural hemorrhage) within 90 days prior to enrollment; * Severe hematological disorders or significant coagulation abnormalities; * Pregnant or breastfeeding women; * Participation in another clinical trial within the past 3 months or ongoing participation; * Any other circumstances deemed by the investigator as unsuitable for participation in this clinical study.