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EC50 of Ciprofol Combined With Remifentanil for Inhibiting Tracheal Responses in Patients Undergoing Gynecological Surgery: a Two-phase Up-and-down Sequential Allocation Study
Sponsor: Guangzhou General Hospital of Guangzhou Military Command
Summary
1. The combined induction of intubation with propofol and remifentanil is widely used in clinical anesthesia, primarily through a single intravenous injection. Target-controlled infusion (TCI) technology, which combines pharmacology with clinical practice, offers a more stable and precise infusion mode; 2. This project aims to explore the half-effective concentration (EC50) of propofol combined with remifentanil for inhibiting tracheal intubation stimulation through a sequential approach under the monitoring of qNOX pain index.
Key Details
Gender
All
Age Range
19 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
66
Start Date
2026-03-03
Completion Date
2026-04-06
Last Updated
2026-09-16
Healthy Volunteers
No
Conditions
Interventions
Cipofol combined with remifentanil administered via target-controlled infusion
Cipofol combined with remifentanil administered via target-controlled infusion for inhibiting tracheal intubation stimulation in adults under qNOX pain index monitoring.
Locations (1)
The Third Affliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China