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Chinese Classics Recitation Training in Subjective Cognitive Decline
Sponsor: China Medical University Hospital
Summary
Subjective cognitive decline (SCD) is considered a preclinical condition associated with an increased risk of dementia and Alzheimer's disease. Effective early behavioral interventions remain limited, and the neurobiological mechanisms underlying cognitive training effects are not fully understood, particularly in culturally specific educational contexts. This randomized, assessor-blinded, controlled clinical trial will enroll 60 individuals with SCD to evaluate the effects of a six-month structured Chinese Classics recitation training program. Participants will be randomly assigned to either an intervention group or a non-active control group. Assessments will be conducted at baseline, immediately post-intervention, and during annual follow-up. Multimodal evaluations will include neuropsychological testing, functional magnetic resonance imaging (fMRI), electroencephalography (EEG), blood biomarker profiling, gut microbiota analysis, and fecal metabolomics. The study aims to examine clinical outcomes and explore potential neurobiological and systemic correlates associated with culturally adapted cognitive training.
Official title: The Effect of Memory Training by Chinese Classics Recitation on Individuals With Subjective Cognitive Decline
Key Details
Gender
All
Age Range
60 Years - Any
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2026-08-01
Completion Date
2032-12-31
Last Updated
2026-03-11
Healthy Volunteers
No
Interventions
Memory training by Chinese Classics recitation
At least five minutes memory training per day, for six months
Locations (1)
China Medical University Hospital
Taichung, Taiwan