Clinical Research Directory

Inclusion Criteria: 1. Adult participants of at least 18 years of age 2. Undergoing uni-or bilateral surgical procedures of the breast(s) anticipated to result in at least moderate pain (NRS \> 3) 3. Planned single-injection peripheral nerve block(s) Exclusion Criteria: 1. Chronic opioid or tramadol use (daily within prior 2 weeks and duration \> 4 weeks) 2. Neurological deficit of the surgical area 3. History of opioid misuse or dependence 4. Renal impairment with a GFR\<15 5. Hepatic impairment (Child-Pugh Class B or C) 6. Use of a moderate or strong CYP3A inhibitor in the week before or plan for use the week after surgery 7. Current use of hormonal contraceptive containing progestins other than levonorgestrel and norethindrone, physiologic potential for pregnancy, anticipated sexual activity within the first postoperative month, and unwillingness to use additional nonhormonal contraception 8. Incarceration 9. Pregnancy 10. Inability to contact the investigators during the treatment period, and vice versa (e.g., lack of telephone access)