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Transcriptomic Profile Changes in Benign Tracheal Stenosis: Wedge Resection vs. Radial Incision
Sponsor: University of Maryland, Baltimore
Summary
Some people develop a narrowing of their windpipe (trachea), called benign tracheal stenosis, which can make it hard to breathe. Doctors often treat this by using a bronchoscope-a thin, flexible tube with a camera-to open up the airway or remove scar tissue. While these procedures help patients breathe better, we do not fully understand why the narrowing occurs or how the tissue heals afterward. The purpose of this study is to better understand the biological changes in the airway tissue before and after these standard medical procedures. During the procedure, small samples of tissue that would already be collected as part of normal care will be analyzed in the laboratory. The results may help doctors learn more about airway healing and could guide better treatments in the future.
Official title: A Randomized Controlled Trial Comparing Transcriptomic Profile Changes Following Carbon Dioxide (CO2) Laser Wedge Resection Versus Radial Incision for Benign Tracheal Stenosis
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2026-05-01
Completion Date
2032-05-01
Last Updated
2026-03-16
Healthy Volunteers
No
Conditions
Interventions
Bronchoscopy, carbon dioxide (CO2) laser wedge resection
CO2 laser wedge resection - removing scar tissue with laser, leading tissue bridges.
Radial incision with dilation
Radial incision with dilation - making radial cuts at the circumferential scar site, followed by balloon dilation.
Locations (1)
University of Maryland
Baltimore, Maryland, United States