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RECRUITING
NCT07463846
PHASE1/PHASE2

A Study to Evaluate ALN-2232 in Participants With Obesity

Sponsor: Alnylam Pharmaceuticals

View on ClinicalTrials.gov

Summary

The purpose of this study is to: * evaluate the safety, tolerability, efficacy, pharmacokinetics (PK), and pharmacodynamics (PD) of single ascending doses of ALN-2232 in patients with obesity * evaluate the safety, tolerability, efficacy, PK, and PD of multiple doses of ALN-2232 in patients with obesity * evaluate the safety, tolerability, efficacy, PK, and PD of multiple doses of ALN-2232 co-initiated with tirzepatide in patients with obesity

Official title: A Phase 1/2, Randomized, Double-blind, Placebo-controlled, Study of the Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of ALN-2232 as Monotherapy and Co-initiated With Tirzepatide in Adult Participants With Obesity

Key Details

Gender

All

Age Range

18 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

156

Start Date

2026-03-02

Completion Date

2028-03-01

Last Updated

2026-03-11

Healthy Volunteers

No

Conditions

Interventions

DRUG

ALN-2232

ALN-2232 will be administered subcutaneously (SC)

DRUG

Placebo

Placebo will be administered SC

DRUG

Tirzepatide

Tirzepatide will be administered SC

Locations (1)

Clinical Trial Site

Montreal, Canada