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A Study to Evaluate ALN-2232 in Participants With Obesity
Sponsor: Alnylam Pharmaceuticals
Summary
The purpose of this study is to: * evaluate the safety, tolerability, efficacy, pharmacokinetics (PK), and pharmacodynamics (PD) of single ascending doses of ALN-2232 in patients with obesity * evaluate the safety, tolerability, efficacy, PK, and PD of multiple doses of ALN-2232 in patients with obesity * evaluate the safety, tolerability, efficacy, PK, and PD of multiple doses of ALN-2232 co-initiated with tirzepatide in patients with obesity
Official title: A Phase 1/2, Randomized, Double-blind, Placebo-controlled, Study of the Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of ALN-2232 as Monotherapy and Co-initiated With Tirzepatide in Adult Participants With Obesity
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
156
Start Date
2026-03-02
Completion Date
2028-03-01
Last Updated
2026-03-11
Healthy Volunteers
No
Conditions
Interventions
ALN-2232
ALN-2232 will be administered subcutaneously (SC)
Placebo
Placebo will be administered SC
Tirzepatide
Tirzepatide will be administered SC
Locations (1)
Clinical Trial Site
Montreal, Canada