Clinical Research Directory

Inclusion Criteria: * Age ≥ 18 years * No patients with other ophthalmic diseases than DED * Chronic dry eye defined as longer than six months since diagnosis * OSDI score \> 22 * Conjunctival Hyperemia ≥ Grade 3 (Efron Scale) * Current use of tear substitutes for at least 3 months * Need to add cyclosporine eye drops to tear substitutes as judged by treating physician prior to and independently of study participation Exclusion Criteria: Ophthalmic exclusion criteria * Far best corrected visual acuity \< 1/10 * Severe Dry Eye associated with: * Eyelid malposition * Stevens Johnson Syndrome * Corneal dystrophy * Ocular neoplasia * Filamentous keratitis * Corneal neovascularisation * Orbital radiotherapy * Dry eye related to Graft Versus Host Disease (GVHD) * History of any of the following within last 3 months: * Systemic treatment of dry eye * Systemic treatment of Meibomian Gland Dysfunction (MGD) * Isotretinoïde, * Cyclosporine, * Tacrolimus, Siromilus, Pimecrolimus * Punctual plugs * History of any of the following within previous six months: * ocular trauma * ocular infection, Ocular allergy * History of any of the following within last 12 months: * inflammatory corneal ulcer * Herpetic eye infection * Uveitis * Ocular surgery Exclusion criteria related to general conditions: * Inability of patient to understand the investigation procedures and thus inability to give valid, informed consent. * Non-compliant patient (e.g. not willing to attend the follow-up visits, way of life interfering with compliance) * Participation in another clinical study or clinical investigation at the same time as the present investigation * Participation to the present clinical investigation during the exclusion period of another clinical study * Patient already included once in this clinical investigation * Patient under guardianship