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Advanced Brain Imaging-TKA (fMRI-TKA)
Sponsor: Ottawa Hospital Research Institute
Summary
Knee replacement surgery is a common and effective treatment for pain and mobility loss, yet up to 1 in 5 patients remain dissatisfied after surgery due to ongoing pain or difficulty with daily activities. Currently, clinicians cannot reliably predict which patients will experience these challenges. This study uses MRI scan of the brain to investigate whether specific patterns of brain activity can predict patient satisfaction after total knee arthroplasty (TKA). By comparing brain networks before surgery and afterward, and linking these changes to patient-reported pain and function, we aim to identify brain-based markers that can help predict outcomes, to improve satisfaction after knee replacement surgery.
Official title: Brain Network-based Precision Medicine to Predict Dissatisfaction Following Total Knee Arthroplasty
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2026-04-01
Completion Date
2028-12-31
Last Updated
2026-03-11
Healthy Volunteers
No
Conditions
Interventions
fMRI Brain Scan
A research brain MRI scan will be performed on a 3T scanner. The MRI session will take approximately 50 minutes of scanning time. The MRI scan will be repeated again 2 months after surgery.
Locations (1)
The Ottawa Hospital
Ottawa, Ontario, Canada